Channel-like functions of the 18-kDa translocator protein (TSPO): regulation of apoptosis and steroidogenesis as part of the host-defense response
L Veenman, V Papadopoulos… - Current pharmaceutical …, 2007 - ingentaconnect.com
Due to its channel-like properties, the peripheral-type benzodiazepine receptor (PBR) has
been renamed the translocator protein (TSPO). In eukaryotes, the TSPO is primarily located …
been renamed the translocator protein (TSPO). In eukaryotes, the TSPO is primarily located …
Mechanism of mitochondrial uncouplers, inhibitors, and toxins: focus on electron transfer, free radicals, and structure-activity relationships
P Kovacic, RS Pozos, R Somanathan… - Current medicinal …, 2005 - ingentaconnect.com
The biology of the mitochondrial electron transport chain is summarized. Our approach to
the mechanism of uncouplers, inhibitors, and toxins is based on electron transfer (ET) and …
the mechanism of uncouplers, inhibitors, and toxins is based on electron transfer (ET) and …
DPA-714, a new translocator protein–specific ligand: Synthesis, radiofluorination, and pharmacologic characterization
The translocator protein (18 kDa)(TSPO), formerly known as the peripheral benzodiazepine
receptor, is dramatically upregulated under pathologic conditions. Activated microglia are …
receptor, is dramatically upregulated under pathologic conditions. Activated microglia are …
The peripheral-type benzodiazepine receptor and the cardiovascular system. Implications for drug development
L Veenman, M Gavish - Pharmacology & therapeutics, 2006 - Elsevier
Peripheral-type benzodiazepine receptors (PBRs) are abundant in the cardiovascular
system. In the cardiovascular lumen, PBRs are present in platelets, erythrocytes …
system. In the cardiovascular lumen, PBRs are present in platelets, erythrocytes …
Role of the hypothalamic-pituitary-adrenal axis, glucocorticoids and glucocorticoid receptors in toxic sequelae of exposure to bacterial and viral products
JI Webster, EM Sternberg - Journal of Endocrinology, 2004 - joe.bioscientifica.com
The present study was undertaken to investigate heat stress protein (HSP)-70 mRNA
induction and p38 MAP kinase (MAPK) activity in response to ischaemic stress in the …
induction and p38 MAP kinase (MAPK) activity in response to ischaemic stress in the …
[HTML][HTML] Epigallocatechin-3-gallate prevents oxidative phosphorylation deficit and promotes mitochondrial biogenesis in human cells from subjects with Down's …
D Valenti, D De Rasmo, A Signorile, L Rossi… - … et Biophysica Acta (BBA …, 2013 - Elsevier
A critical role for mitochondrial dysfunction has been proposed in the pathogenesis of
Down's syndrome (DS), a human multifactorial disorder caused by trisomy of chromosome …
Down's syndrome (DS), a human multifactorial disorder caused by trisomy of chromosome …
Microglial pro-inflammatory and anti-inflammatory phenotypes are modulated by translocator protein activation
E Da Pozzo, C Tremolanti, B Costa… - International journal of …, 2019 - mdpi.com
A key role of the mitochondrial Translocator Protein 18 KDa (TSPO) in neuroinflammation
has been recently proposed. However, little is known about TSPO-activated pathways …
has been recently proposed. However, little is known about TSPO-activated pathways …
Genipin-induced apoptosis in hepatoma cells is mediated by reactive oxygen species/c-Jun NH2-terminal kinase-dependent activation of mitochondrial pathway
Genipin, the aglycone of geniposide, exhibits anti-inflammatory and anti-angiogenic
activities. Here we demonstrate that genipin induces apoptotic cell death in FaO rat …
activities. Here we demonstrate that genipin induces apoptotic cell death in FaO rat …
Toward highly potent cancer agents by modulating the C-2 group of the arylthioindole class of tubulin polymerization inhibitors
G La Regina, R Bai, WM Rensen… - Journal of medicinal …, 2013 - ACS Publications
New arylthioindole derivatives having different cyclic substituents at position 2 of the indole
were synthesized as anticancer agents. Several compounds inhibited tubulin polymerization …
were synthesized as anticancer agents. Several compounds inhibited tubulin polymerization …
Therapeutic targets and potential of the novel brain‐permeable multifunctional iron chelator–monoamine oxidase inhibitor drug, M‐30, for the treatment of Alzheimer's …
Y Avramovich‐Tirosh, T Amit, O Bar‐Am… - Journal of …, 2007 - Wiley Online Library
Novel therapeutic approaches for the treatment of neurodegenerative disorders comprise
drug candidates designed specifically to act on multiple CNS targets. We have synthesized …
drug candidates designed specifically to act on multiple CNS targets. We have synthesized …