Integrins are heterodimeric cell surface receptors ensuring the mechanical connection
between cells and the extracellular matrix. In addition to the anchorage of cells to the …

Integrins are heterodimeric cell adhesion molecules that link the extracellular matrix to the
cytoskeleton. The integrin family in man comprises 24 members, which are the result of …

Four decades have passed since the first discovery of collagen IV by Kefalides in 1966.
Since then collagen IV has been investigated extensively by a large number of research …

After dissemination from a primary tumor, cancer cells may resume growth, leading to overt
metastasis, or enter a state of protracted dormancy. However, mechanisms that determine …

Cutaneous wound healing is a highly coordinated physiological process that rapidly and
efficiently restores skin integrity. Reepithelization is a crucial step during wound healing …

Metastasis, the process by which cancer cells leave the primary tumour, disseminate and
form secondary tumours at anatomically distant sites, is a serious clinical problem as it is …

Mice that are mutant for Reelin or Dab1, or doubly mutant for the VLDL receptor (VLDLR)
and ApoE receptor 2 (ApoER2), show disorders of cerebral cortical lamination. How Reelin …

Significance: Regulation of cell adhesions during tissue repair is fundamentally important for
cell migration, proliferation, and protein production. All cells interact with extracellular matrix …

Laminins are a family of trimeric glycoproteins present in the extracellular matrix and the
major constituents of basement membranes. Integrins are αβ transmembrane receptors that …

Integrin α3 is a transmembrane integrin receptor subunit that mediates signals between the
cells and their microenvironment. We identified three patients with homozygous mutations in …