Capillaroscopy is a non-invasive and safe tool which allows the evaluation of the
morphology of the microcirculation. Since its recent incorporation in the 2013 American …

Systemic sclerosis is a complex autoimmune disease characterized by a chronic and
frequently progressive course and by extensive patient-to-patient variability. Like other …

Raynaud phenomenon is a symptom complex caused by impaired digital perfusion and can
occur as a primary phenomenon or secondary to a wide range of underlying causes …

Scleroderma refers to an autoimmune connective tissue fibrosing disease, including three
different subsets: localized scleroderma, limited cutaneous systemic sclerosis, and diffuse …

Video nailfold capillaroscopy (NFC), considered as an extension of the widefield technique,
allows a more accurate measuring and storing of capillary data and a better defining …

The past 10 years have seen the publication of results from several multicentre clinical trials
in primary and systemic sclerosis (SSc)-related Raynaud phenomenon. The publication of …

Microvascular damage and dysfunction represent the earliest morphological and functional
markers of systemic sclerosis (SSc), a progressive connective tissue disease characterized …

Digital ulcers (DUs) are a common visible manifestation of the progressive vascular disease
that characterizes the SSc disease process. DUs not only impact significantly on patients' …

Systemic sclerosis (SSc) is a complex autoimmune connective tissue disease which is
characterised by autoimmunity, widespread tissue fibrosis of the skin and internal organs …

Background: Rising data suggest that COVID-19 affects vascular endothelium while the
underlying mechanisms promoting COVID-19-associated endothelial dysfunction and …