Dissolution and absorption of inhaled drug particles in the lungs

BB Eedara, R Bastola, SC Das - Pharmaceutics, 2022 - mdpi.com
Dry powder inhalation therapy has been effective in treating localized lung diseases such
asthma, chronic obstructive pulmonary diseases (COPD), cystic fibrosis and lung infections …

Factors influencing the bioavailability of organic molecules to bacterial cells—A mini-review

W Smułek, E Kaczorek - Molecules, 2022 - mdpi.com
The bioavailability of organic compounds to bacterial cells is crucial for their vital activities.
This includes both compounds that are desirable to the cells (eg, sources of energy, carbon …

[HTML][HTML] Co-interaction of nitrofurantoin and saponins surfactants with biomembrane leads to an increase in antibiotic's antibacterial activity

W Smułek, M Rojewska, A Pacholak… - Journal of Molecular …, 2022 - Elsevier
Limited bioavailability of antibiotics is an urgent problem in the treatment of microbial
infections. To increase transport of nitrofurantoin (NFT) into the bacterial cells the proposed …

Study of interactions between saponin biosurfactant and model biological membranes: phospholipid monolayers and liposomes

M Rojewska, W Smułek, A Grzywaczyk, E Kaczorek… - Molecules, 2023 - mdpi.com
The aim of this study was to determine the effect of saponins-rich plant extract on two model
biological membranes: phospholipid monolayers and liposomes. The Langmuir monolayer …

Bacterial membrane mimetics: From biosensing to disease prevention and treatment

SS Arya, NK Morsy, DK Islayem, SA Alkhatib… - Biosensors, 2023 - mdpi.com
Plasma membrane mimetics can potentially play a vital role in drug discovery and
immunotherapy owing to the versatility to assemble facilely cellular membranes on surfaces …

Biophysical interaction of gold nanoparticles with model biological membranes: Investigation of the effect of geometry on cellular uptake and photothermal …

GD Kalaycioglu, BO Altas, N Aydogan - Colloids and Surfaces A …, 2023 - Elsevier
Gold nanoparticles (AuNPs) with different geometry have been demonstrated to provide
significant advantages in enhancing cellular uptake and improving the efficacy of …

Solid and Liquid Surface-Supported Bacterial Membrane Mimetics as a Platform for the Functional and Structural Studies of Antimicrobials

S Li, R Ren, L Lyu, J Song, Y Wang, TW Lin, AL Brun… - Membranes, 2022 - mdpi.com
Increasing antibiotic resistance has provoked the urgent need to investigate the interactions
of antimicrobials with bacterial membranes. The reasons for emerging antibiotic resistance …

Effect of Silica Microparticles on Interactions in Mono-and Multicomponent Membranes

B Tim, M Rojewska, K Prochaska - International Journal of Molecular …, 2022 - mdpi.com
Advancing our understanding of the mechanism of the interaction between inhaled pollutant
microparticles and cell membrane components is useful to study the impact of fine …

Penicillin-binding proteins (PBPs) determine antibiotic action in Langmuir monolayers as nanoarchitectonics mimetic membranes of methicillin-resistant …

BA Martins, E Deffune, ON Oliveira Jr… - Colloids and Surfaces B …, 2022 - Elsevier
The membrane of methicillin-resistant Staphylococcus aureus (MRSA) contains penicillin-
binding proteins (PBPs) in the phospholipidic bilayer, with the protein PBP2a being linked …

Bragg–Williams Theory for Particles with a Size-Modulating Internal Degree of Freedom

GV Bossa, S May - Molecules, 2023 - mdpi.com
The field of soft matter teems with molecules and aggregates of molecules that have internal
size-modulating degrees of freedom. Proteins, peptides, microgels, polymers, micelles, and …