Desirable cells for human cell therapy would be ones that can be generated by simple
isolation and culture techniques using a donor sample obtained by non-invasive methods …

All living cells utilize intricate DNA repair mechanisms to address numerous types of DNA
lesions and to preserve genomic integrity, and pluripotent stem cells have specific needs …

Induced pluripotent stem cells (iPSCs) hold great promise for modeling human
hematopoietic diseases. However, intrinsic variability in the capacities of different iPSC lines …

A defined xeno-free system for patient-specific iPSC derivation and differentiation is required
for translation to clinical applications. However, standard somatic cell reprogramming …

Hematopoietic cell transplantation (HCT) has become a standard practice to treat a number
of malignant and nonmalignant hematologic diseases. Bone marrow, mobilized peripheral …

Cell therapy, ie., the use of cells to repair an affected tissue or organ, is at the forefront of
regenerative and personalized medicine. Among the multiple cell types that have been used …

Research over the last few years in cellular reprogramming has enlightened the magical
potential of microRNAs (miRNAs) in changing the cell fate from somatic to pluripotent …

The genetic cardiomyopathies are a group of disorders related by abnormal myocardial
structure and function. Although individually rare, these diseases collectively represent a …

Effective and efficient generation of human neural stem cells and subsequently functional
neural populations from pluripotent stem cells has facilitated advancements in the study of …

Induced reprogramming of somatic cells has had a great impact on stem cell research, and
the reprogramming technologies have evolved from four transgenic factors (Oct4, Sox2, Klf4 …