The connexin family of channel-forming proteins is present in every tissue type in the human
anatomy. Connexins are best known for forming clustered intercellular channels, structurally …

Connexins are ubiquitous channel forming proteins that assemble as plasma membrane
hemichannels and as intercellular gap junction channels that directly connect cells. In the …

While gap junctions support the exchange of a number of molecules between neighboring
cells, connexin hemichannels provide communication between the cytosol and the …

Abstract Connexin43 (Cx43) hemichannels in spinal cord astrocytes are implicated in the
maintenance of neuropathic pain following peripheral nerve injury. Peptide5 is a Cx43 …

The maintenance of tissue, organ, and organism homeostasis relies on an intricate network
of players and mechanisms that assist in the different forms of cell–cell communication …

Over the past several decades a large amount of data have established that glial cells, the
main cell population in the brain, dynamically interact with neurons and thus impact their …

Background Connexin43 hemichannels have been implicated in many inflammatory
diseases including diabetic retinopathy (DR). Particularly, hemichannel-mediated ATP …

Connexins, in particular connexin 43 (Cx43), function as gap junction channels (GJCs) and
hemichannels (HCs). Only recently, specific tools have been developed to study their …

Increased Connexin43 hemichannel opening is associated with inflammasome pathway
activation and inflammation in a range of pathologies including ocular disorders, such as …

Background Without a viable cure, chronic kidney disease is a global health concern.
Inflammatory damage in and around the renal tubules dictates disease severity and is …