Interventions to prevent pregnancy complications have been largely unsuccessful. We
suggest this is because the foundation for a healthy pregnancy is laid prior to the …

During pregnancy, several tightly coordinated and regulated processes take place to enable
proper fetal development and gestational success. The formation and development of the …

Pregnancy involves a complex interplay between maternal neuroendocrine and
immunological systems in order to establish and sustain a growing fetus. It is thought that the …

OBJECTIVE: To determine whether the use of vaginal progesterone in asymptomatic women
with a sonographic short cervix (≤ 25 mm) in the midtrimester reduces the risk of preterm …

Nearly all breast cancer deaths result from metastatic disease. Despite this, the genomic
events that drive metastatic recurrence are poorly understood. We performed whole-exome …

The role of membrane progesterone receptors (mPRs), which belong to the progestin and
adipoQ receptor (PAQR) family, in mediating rapid, nongenomic (non-classical) …

Rapid effects of steroid hormones were discovered in the early 1950s, but the subject was
dominated in the 1970s by discoveries of estradiol and progesterone stimulating protein …

Steroids play an important role in the regulation of normal physiology and the treatment of
disease. Steroid receptors have classically been described as ligand-activated transcription …

Progesterone is an essential hormone in the process of reproduction. It is involved in the
menstrual cycle, implantation and is essential for pregnancy maintenance. It has been …

Gender-associated differences in the development of cardiovascular diseases have been
described in humans and animals. These differences could explain the low incidence of …