This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …

The CLDN5 gene encodes claudin-5 (CLDN-5) that is expressed in endothelial cells and
forms tight junctions which limit the passive diffusions of ions and solutes. The blood–brain …

Mammalian biology adapts to physical activity but the molecular mechanisms sensing the
activity remain enigmatic. Recent studies have revealed how Piezo1 protein senses …

Mechanical forces influence different cell types in our bodies. Among the earliest forces
experienced in mammals is blood movement in the vascular system. Blood flow starts at the …

Vascular endothelial cells (ECs) form a semiselective barrier for macromolecules and cell
elements regulated by dynamic interactions between cytoskeletal elements and cell …

Endothelial cells in resistance arteries, arterioles, and capillaries express a diverse array of
ion channels that contribute to Cell-Cell communication in the microcirculation. Endothelial …

Coronary microvascular disease (CMD), which affects the arterioles and capillary
endothelium that regulate myocardial perfusion, is an increasingly recognized source of …

As described in the literature the interaction between cholesterol and membrane proteins
can occur via direct, ligand-like and indirect mechanisms, in which cholesterol effects are …

Abstract Pannexin 1 (Panx1), an ATP-efflux pathway, has been linked with inflammation in
pulmonary capillaries. However, the physiological roles of endothelial Panx1 in the …

The phosphoinositide, phosphatidylinositol 4, 5-bisphosphate (PIP2), has long been
established as a major contributor to intracellular signaling, primarily by virtue of its role as a …