▪ Abstract The phytohemagglutinin-induced virus-inhibitor may, however, be produced in
white cells in response to a stimulation of cellular RNA synthesis and may be a feedback …

Interferon regulatory factors (IRFs) constitute a family of transcription factors that commonly
possess a novel helix-turn-helix DNA-binding motif. Following the initial identification of two …

Glioblastoma multiforme (GBM) is an aggressive brain tumor for which current
immunotherapy approaches have been unsuccessful. Here, we explore the mechanisms …

The interferon regulatory factor (IRF) family, consisting of nine members in mammals, was
identified in the late 1980s in the context of research into the type I interferon system …

The interferon regulatory factors (IRF) consist of a growing family of related transcription
proteins first identified as regulators of the alpha beta interferon (IFN-α/β) gene promoters …

It has been hypothesized that certain viral infections directly activate a transcription factor (s)
which is responsible for the activation of genes encoding type I interferons (IFNs) and …

In recent years, great progress has been made in elucidating the progenitor-cell hierarchy of
the myeloid lineage. Transcription factors have been shown to be key determinants in the …

The promoter region of the mouse gene for macrophage-inducible nitric oxide synthase
(mac-NOS; EC 1.14. 13.39) has been characterized. A putative TATA box is 30 base pairs …

Members of the interferon-regulatory factor (IRF) proteins family were originally identified as
transcriptional regulators of the Type I interferon system. Thanks to consistent advances …

Inflammasome activation is critical for host defenses against various microbial infections.
Activation of the NLRC4 inflammasome requires detection of flagellin or type III secretion …