Pathological changes within the cerebral vasculature in Alzheimer's disease: New perspectives

RA Fisher, JS Miners, S Love - Brain Pathology, 2022 - Wiley Online Library
Cerebrovascular disease underpins vascular dementia (VaD), but structural and functional
changes to the cerebral vasculature contribute to disease pathology and cognitive decline in …

The gut–immune–brain axis: an important route for neuropsychiatric morbidity in inflammatory bowel disease

RK Masanetz, J Winkler, B Winner, C Günther… - International Journal of …, 2022 - mdpi.com
Inflammatory bowel disease (IBD) comprises Crohn's disease (CD) and ulcerative colitis
(UC) and is associated with neuropsychiatric symptoms like anxiety and depression. Both …

Microglial hexokinase 2 deficiency increases ATP generation through lipid metabolism leading to β-amyloid clearance

L Leng, Z Yuan, R Pan, X Su, H Wang, J Xue… - Nature …, 2022 - nature.com
Microglial cells consume adenosine triphosphate (ATP) during phagocytosis to clear
neurotoxic β-amyloid in Alzheimer's disease (AD). However, the contribution of energy …

The joint-brain axis: insights from rheumatoid arthritis on the crosstalk between chronic peripheral inflammation and the brain

P Süß, T Rothe, A Hoffmann, JCM Schlachetzki… - Frontiers in …, 2020 - frontiersin.org
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by erosive
polyarthritis. Beyond joint pathology, RA is associated with neuropsychiatric comorbidity …

The therapeutic and diagnostic potential of amyloid β oligomers selective antibodies to treat Alzheimer's disease

KL Viola, MA Bicca, AM Bebenek, DL Kranz… - Frontiers in …, 2022 - frontiersin.org
Improvements have been made in the diagnosis of Alzheimer's disease (AD), manifesting
mostly in the development of in vivo imaging methods that allow for the detection of …

[HTML][HTML] Single-cell and spatial transcriptomics reveals that PTPRG activates the m6A methyltransferase VIRMA to block mitophagy-mediated neuronal death in …

D Zou, X Huang, Y Lan, M Pan, J Xie, Q Huang… - Pharmacological …, 2024 - Elsevier
Neuronal death is one of the key pathologies in Alzheimer's disease (AD). How neuronal
death begins in AD is far from clear, so clarifying this process may help develop effective …

Non-steroidal anti-inflammatory drugs as candidates for the prevention or treatment of Alzheimer's disease: do they still have a role?

A Villarejo-Galende… - Current Alzheimer …, 2020 - ingentaconnect.com
Purpose of Review: To provide an updated analysis of the possible use of non-steroidal anti-
inflammatory drugs (NSAIDs) as treatments for Alzheimer´ s disease (AD). Recent Findings …

Microglia Signaling in Health and Disease–Implications in Sex-Specific Brain Development and Plasticity

S Pramanik, MH Devi, S Chakrabarty, B Paylar… - Neuroscience & …, 2024 - Elsevier
Microglia, the intrinsic neuroimmune cells residing in the central nervous system (CNS),
exert a pivotal influence on brain development, homeostasis, and functionality …

Stress response and hearing loss differentially contribute to dynamic alterations in hippocampal neurogenesis and microglial reactivity in mice exposed to acute noise …

Q Li, H Li, X Yao, C Wang, H Liu, D Xu… - Frontiers in …, 2021 - frontiersin.org
Noise-induced hearing loss (NIHL) is one of the most prevalent forms of acquired hearing
loss, and it is associated with aberrant microglial status and reduced hippocampal …

Alzheimer's disease neuropathology is exacerbated following traumatic brain injury. Neuroprotection by co-administration of nanowired mesenchymal stem cells and …

HS Sharma, DF Muresanu, A Nozari… - Progress in Brain …, 2021 - Elsevier
Military personnel are prone to traumatic brain injury (TBI) that is one of the risk factors in
developing Alzheimer's disease (AD) at a later stage. TBI induces breakdown of the blood …