This review describes the structure and functions of Y-box binding protein 1 (YB-1) and its
homologs. Interactions of YB-1 with DNA, mRNAs, and proteins are considered. Data on the …

BACKGROUND: Taxanes are established in the treatment of metastatic breast cancer (MBC)
and early breast cancer (EBC) as potent chemotherapy agents. However, their therapeutic …

The Y Box binding protein 1 (YB-1) is a member of the highly conserved Cold Shock Domain
protein family with multifunctional properties both in the cytoplasm and inside the nucleus …

The discovery of predictive factors for chemoresistance is critical for improving adjuvant
therapy for cancer patients. The 78-kDa glucose-regulated protein (GRP78), widely used as …

The mammalian AP-endonuclease (APE1/Ref-1) plays a central role in the repair of oxidized
and alkylated bases in mammalian genomes via the base excision repair (BER) pathway …

Background We previously found focal adhesion kinase (FAK) inhibition sensitizes ovarian
cancer to taxanes; however, the mechanisms are not well understood. Methods We …

Y box binding protein 1 (YB-1) is a protein with a highly conserved cold shock domain (CSD)
that also belongs to the family of DNA-and RNA-binding proteins. YB-1 is present in both the …

Development of drug resistance is one of the major causes of breast cancer treatment
failure. The goal of this study was to understand the chemoresistance mechanism using the …

Y‐box binding protein‐1 (YBX 1), a multifunctional oncoprotein containing an evolutionarily
conserved cold shock domain, dysregulates a wide range of genes involved in cell …

Programmed cell death protein 4 (PDCD4) has recently been shown to be involved in both
transcription and translation, and to regulate cell growth. However, the mechanisms …