Carboxylic acids as adaptive functional groups in metallaphotoredox catalysis
Conspectus The development of palladium-catalyzed cross-coupling methods for the
activation of C (sp2)–Br bonds facilitated access to arene-rich molecules, enabling a …
activation of C (sp2)–Br bonds facilitated access to arene-rich molecules, enabling a …
Photocatalysis in the life science industry
L Candish, KD Collins, GC Cook, JJ Douglas… - Chemical …, 2021 - ACS Publications
In the pursuit of new pharmaceuticals and agrochemicals, chemists in the life science
industry require access to mild and robust synthetic methodologies to systematically modify …
industry require access to mild and robust synthetic methodologies to systematically modify …
Carbon-centered radical capture at nickel (II) complexes: Spectroscopic evidence, rates, and selectivity
Q Lin, EH Spielvogel, T Diao - Chem, 2023 - cell.com
The capture of carbon-centered radicals at a nickel (II) center is commonly featured in recent
cross-coupling and metallaphotoredox catalytic reactions. Despite its widespread …
cross-coupling and metallaphotoredox catalytic reactions. Despite its widespread …
Oxetanes in drug discovery campaigns
JJ Rojas, JA Bull - Journal of Medicinal Chemistry, 2023 - ACS Publications
The oxetane ring is an emergent, underexplored motif in drug discovery that shows attractive
properties such as low molecular weight, high polarity, and marked three-dimensionality …
properties such as low molecular weight, high polarity, and marked three-dimensionality …
Visible light–mediated aza Paternò–Büchi reaction of acyclic oximes and alkenes to azetidines
The aza Paternò–Büchi reaction is a [2+ 2]-cycloaddition reaction between imines and
alkenes that produces azetidines, four-membered nitrogen-containing heterocycles …
alkenes that produces azetidines, four-membered nitrogen-containing heterocycles …
Nickel-Catalyzed Electroreductive Coupling of Alkylpyridinium Salts and Aryl Halides
J Fu, W Lundy, R Chowdhury, JC Twitty, LP Dinh… - ACS …, 2023 - ACS Publications
An electrochemical, nickel-catalyzed reductive coupling of alkylpyridinium salts and aryl
halides is reported. High-throughput experimentation (HTE) was employed for rapid reaction …
halides is reported. High-throughput experimentation (HTE) was employed for rapid reaction …
Control of Redox‐Active Ester Reactivity Enables a General Cross‐Electrophile Approach to Access Arylated Strained Rings
DC Salgueiro, BK Chi, IA Guzei… - Angewandte Chemie …, 2022 - Wiley Online Library
Strained rings are increasingly important for the design of pharmaceutical candidates, but
cross‐coupling of strained rings remains challenging. An attractive, but underdeveloped …
cross‐coupling of strained rings remains challenging. An attractive, but underdeveloped …
Azetidines with All-Carbon Quaternary Centers: Merging Relay Catalysis with Strain Release Functionalization
CM Hsu, HB Lin, XZ Hou, RVPP Tapales… - Journal of the …, 2023 - ACS Publications
Given the importance and beneficial characteristics of decorated azetidines in medicinal
chemistry, efficient strategies for their synthesis are highly sought after. Herein, we report a …
chemistry, efficient strategies for their synthesis are highly sought after. Herein, we report a …
Mechanistic views and computational studies on transition-metal-catalyzed reductive coupling reactions
A Duan, F Xiao, Y Lan, L Niu - Chemical Society Reviews, 2022 - pubs.rsc.org
Transition-metal-catalyzed reductive coupling reactions have been considered as a
powerful tool to convert two electrophiles into value-added products. Numerous related …
powerful tool to convert two electrophiles into value-added products. Numerous related …
Amino-oxetanes as amide isosteres by an alternative defluorosulfonylative coupling of sulfonyl fluorides
JJ Rojas, RA Croft, AJ Sterling, EL Briggs… - Nature …, 2022 - nature.com
Bioisosteres provide valuable design elements that medicinal chemists can use to adjust the
structural and pharmacokinetic characteristics of bioactive compounds towards viable drug …
structural and pharmacokinetic characteristics of bioactive compounds towards viable drug …