Gangliosides in the brain: physiology, pathophysiology and therapeutic applications
Gangliosides are glycosphingolipids highly abundant in the nervous system, and carry most
of the sialic acid residues in the brain. Gangliosides are enriched in cell membrane …
of the sialic acid residues in the brain. Gangliosides are enriched in cell membrane …
Alcoholic liver disease
HK Seitz, R Bataller, H Cortez-Pinto, B Gao… - Nature reviews Disease …, 2018 - nature.com
Alcoholic liver disease (ALD) is the most prevalent type of chronic liver disease worldwide.
ALD can progress from alcoholic fatty liver (AFL) to alcoholic steatohepatitis (ASH), which is …
ALD can progress from alcoholic fatty liver (AFL) to alcoholic steatohepatitis (ASH), which is …
Specific hepatic sphingolipids relate to insulin resistance, oxidative stress, and inflammation in nonalcoholic steatohepatitis
M Apostolopoulou, R Gordillo, C Koliaki… - Diabetes …, 2018 - Am Diabetes Assoc
OBJECTIVE Insulin resistance and nonalcoholic fatty liver disease have been linked to
several lipid metabolites in animals, but their role in humans remains unclear. This study …
several lipid metabolites in animals, but their role in humans remains unclear. This study …
Mitochondrial glutathione, a key survival antioxidant
Mitochondria are the primary intracellular site of oxygen consumption and the major source
of reactive oxygen species (ROS), most of them originating from the mitochondrial …
of reactive oxygen species (ROS), most of them originating from the mitochondrial …
Cytochrome c: functions beyond respiration
YLP Ow, DR Green, Z Hao, TW Mak - Nature reviews Molecular cell …, 2008 - nature.com
Cytochrome c is primarily known for its function in the mitochondria as a key participant in
the life-supporting function of ATP synthesis. However, when a cell receives an apoptotic …
the life-supporting function of ATP synthesis. However, when a cell receives an apoptotic …
Molecular mechanisms of alcohol-mediated carcinogenesis
HK Seitz, F Stickel - Nature Reviews Cancer, 2007 - nature.com
Abstract Approximately 3.6% of cancers worldwide derive from chronic alcohol drinking,
including those of the upper aerodigestive tract, the liver, the colorectum and the breast …
including those of the upper aerodigestive tract, the liver, the colorectum and the breast …
Sphingolipids: regulators of crosstalk between apoptosis and autophagy
MM Young, M Kester, HG Wang - Journal of lipid research, 2013 - ASBMB
Apoptosis and autophagy are two evolutionarily conserved processes that maintain
homeostasis during stress. Although the two pathways utilize fundamentally distinct …
homeostasis during stress. Although the two pathways utilize fundamentally distinct …
Alcohol, oxidative stress and free radical damage
E Albano - Proceedings of the nutrition society, 2006 - cambridge.org
The involvement of free radical mechanisms in the pathogenesis of alcoholic liver disease
(ALD) is demonstrated by the detection of lipid peroxidation markers in the liver and the …
(ALD) is demonstrated by the detection of lipid peroxidation markers in the liver and the …
Ceramide: second messenger or modulator of membrane structure and dynamics?
WJ BLITTERSWIJK, AH LUIT, RJ Veldman… - Biochemical …, 2003 - portlandpress.com
The physiological role of ceramide formation in response to cell stimulation remains
controversial. Here, we emphasize that ceramide is not a priori an apoptotic signalling …
controversial. Here, we emphasize that ceramide is not a priori an apoptotic signalling …
GM1-ganglioside accumulation at the mitochondria-associated ER membranes links ER stress to Ca2+-dependent mitochondrial apoptosis
R Sano, I Annunziata, A Patterson, S Moshiach… - Molecular cell, 2009 - cell.com
Mitochondria-associated ER membranes, or MAMs, define the sites of endoplasmic
reticulum/mitochondria juxtaposition that control Ca 2+ flux between these organelles. We …
reticulum/mitochondria juxtaposition that control Ca 2+ flux between these organelles. We …