Gangliosides are glycosphingolipids highly abundant in the nervous system, and carry most
of the sialic acid residues in the brain. Gangliosides are enriched in cell membrane …

Alcoholic liver disease (ALD) is the most prevalent type of chronic liver disease worldwide.
ALD can progress from alcoholic fatty liver (AFL) to alcoholic steatohepatitis (ASH), which is …

OBJECTIVE Insulin resistance and nonalcoholic fatty liver disease have been linked to
several lipid metabolites in animals, but their role in humans remains unclear. This study …

Mitochondria are the primary intracellular site of oxygen consumption and the major source
of reactive oxygen species (ROS), most of them originating from the mitochondrial …

Cytochrome c is primarily known for its function in the mitochondria as a key participant in
the life-supporting function of ATP synthesis. However, when a cell receives an apoptotic …

Abstract Approximately 3.6% of cancers worldwide derive from chronic alcohol drinking,
including those of the upper aerodigestive tract, the liver, the colorectum and the breast …

Apoptosis and autophagy are two evolutionarily conserved processes that maintain
homeostasis during stress. Although the two pathways utilize fundamentally distinct …

The involvement of free radical mechanisms in the pathogenesis of alcoholic liver disease
(ALD) is demonstrated by the detection of lipid peroxidation markers in the liver and the …

The physiological role of ceramide formation in response to cell stimulation remains
controversial. Here, we emphasize that ceramide is not a priori an apoptotic signalling …

Mitochondria-associated ER membranes, or MAMs, define the sites of endoplasmic
reticulum/mitochondria juxtaposition that control Ca 2+ flux between these organelles. We …