The autophagy–lysosomal pathway (ALP) is involved in the degradation of long-lived
proteins. Deficits in the ALP result in protein aggregation, the generation of toxic protein …

Multiple sclerosis (MS) is a neuroinflammatory disease with limited therapeutic effects,
eventually developing into handicap. Seeking novel therapeutic strategies for MS is timely …

How the highly curved phagophore membrane is stabilized during autophagy initiation is a
major open question in autophagosome biogenesis. Here, we use in vitro reconstitution on …

Autophagy is a primordial eukaryotic pathway, which provides the immune system with
multiple mechanisms for the elimination of invading pathogens including Mycobacterium …

Objective 1, 25 (OH) 2D3 has been reported to attenuate liver steatosis; however, its exact
mechanism of action remains poorly understood. This study aimed to determine whether 1 …

Autophagy is an essential self-digestion machinery for cell survival and homoeostasis.
Membrane elongation is fundamental, as it drives the formation of the double-membrane …

Immune thrombocytopenic purpura (ITP) is a multifactorial autoimmune disease
characterized by both increased platelet destruction and/or reduced platelet production …

In normal physiological condition, the maintenance of cellular proteostasis is a prerequisite
for cell growth, functioning, adapting to changing micro-environments, and responding to …

Mitochondria are essential organelles for healthy eukaryotic cells. They produce energyrich
phosphate bond molecules (ATP) through oxidative phosphorylation using ionic gradients …

Ethnopharmacological relevance The prescription of Yiqi Jiedu decoction (YQJD) originated
from the classic Chinese herbal prescriptions of Danggui Buxue Decoction and Wuzi …