Division of amoebas, fungi, and animal cells into two daughter cells at the end of the cell
cycle depends on a common set of ancient proteins, principally actin filaments and myosin-II …

Cell division—cytokinesis—involves large-scale rearrangements of the entire cell. Primarily
driven by cytoskeletal proteins, cytokinesis also depends on topological rearrangements of …

Septins perform diverse functions through the formation of filaments and higher-order
structures. However, the exact architecture of septin structures remains unclear. In the …

A bidirectional association exists between metastatic dissemination and the
hypercoagulable state associated with many types of cancer. As such, clinical studies have …

Cytokinesis involves constriction of a contractile actomyosin ring. The mechanisms
generating ring tension and setting the constriction rate remain unknown because the …

Cell division is a fundamental but complex process that gives rise to two daughter cells. It
includes an ordered set of events, altogether called “the cell cycle”, that culminate with …

The ability to fluorescently label microtubules in live cells has enabled numerous studies of
motile and mitotic processes. Such studies are particularly useful in budding yeast owing to …

Cytokinesis is essential for the survival of all organisms. It requires concerted functions of
cell signaling, force production, exocytosis, and extracellular matrix remodeling. Due to the …

How septin architecture is remodeled from an hourglass to a double ring during cytokinesis
in fungal and animal cells remains unknown. Here, we show that during the hourglass-to …

In many eukaryotic organisms cytokinesis is driven by a contractile actomyosin ring (CAR)
that guides membrane invagination. What triggers CAR constriction at a precise time of the …