version of the Guidelines, which is freely available via the ESC and EAS websites and
hosted on their journals' websites (EHJ and Atherosclerosis Journal). The National Cardiac …

The Ser and Thr kinase AKT, also known as protein kinase B (PKB), was discovered 25
years ago and has been the focus of tens of thousands of studies in diverse fields of biology …

mTOR [mechanistic target of rapamycin] is a serine/threonine protein kinase that, as part of
mTORC1 (mTOR complex 1), acts as an important molecular connection between nutrient …

In 2009, rapamycin was reported to increase the lifespan of mice when implemented later in
life. This observation resulted in a sea-change in how researchers viewed aging. This was …

An increased risk of cardiovascular disease, independent of conventional risk factors, is
present even at minor levels of renal impairment and is highest in patients with end-stage …

Transcriptional complexes that contain peroxisome-proliferator-activated receptor
coactivator (PGC)-1α control mitochondrial oxidative function to maintain energy …

An enhanced capacity for de novo lipid synthesis is a metabolic feature of most cancer cells
that distinguishes them from their cells of origin. However, the mechanisms through which …

OBJECTIVE The mammalian target of rapamycin (mTOR)/p70 S6 kinase 1 (S6K1) pathway
is a critical signaling component in the development of obesity-linked insulin resistance and …

The mammalian target of rapamycin (mTOR) plays a key role in regulation of cellular
metabolism, growth, and proliferation. The frequent hyperactivation of mTOR signaling …

The mechanistic target of rapamycin complex 1 (mTORC1) senses and relays environmental
signals from growth factors and nutrients to metabolic networks and adaptive cellular …