Monocytes and macrophages provide defence against pathogens and danger signals.
These cells respond to stimulation in a fast and stimulus-specific manner by utilizing …

Nucleotide-binding oligomerization domain-like receptor family pyrin domain containing 3
(NLRP3) is an intracellular innate immune receptor that recognizes a diverse range of …

Trained immunity describes the capacity of innate immune cells to develop heterologous
memory in response to certain exogenous exposures. This phenomenon mediates, at least …

Innate immune cells can adopt long-term inflammatory phenotypes following brief
encounters with exogenous (microbial) or endogenous stimuli. This phenomenon is named …

Caspase-8 is an apical caspase involved in the programmed form of cell death called
apoptosis that is critically important for mammalian development and immunity. Apoptosis …

The process of aging is associated with the appearance of low-grade subclinical
inflammation, termed inflammaging, that can accelerate age-related diseases. In Western …

The NLRP3 inflammasome is a vital part of the innate immune response, whilst its aberrant
activation drives the progression of a number of non-communicable diseases. Thus, NLRP3 …

Atherosclerosis underlies the leading cause of death in industrialized countries. 1
Atherosclerosis is a maladaptive, nonresolving chronic inflammatory disease that occurs …

Innate immune cells can develop exacerbated immunologic response and long-term
inflammatory phenotype following brief exposure to endogenous or exogenous insults …

Inflammation has been long regarded as a key contributor to atherosclerosis. Inflammatory
cells and soluble mediators play critical roles throughout arterial plaque development and …