Mechanism of action of ribosomally synthesized and post-translationally modified peptides

C Ongpipattanakul, EK Desormeaux… - Chemical …, 2022 - ACS Publications
Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a natural
product class that has undergone significant expansion due to the rapid growth in genome …

New developments in RiPP discovery, enzymology and engineering

M Montalbán-López, TA Scott, S Ramesh… - Natural product …, 2021 - pubs.rsc.org
Covering: up to June 2020 Ribosomally-synthesized and post-translationally modified
peptides (RiPPs) are a large group of natural products. A community-driven review in 2013 …

Mechanistic understanding of lanthipeptide biosynthetic enzymes

LM Repka, JR Chekan, SK Nair… - Chemical …, 2017 - ACS Publications
Lanthipeptides are ribosomally synthesized and post-translationally modified peptides
(RiPPs) that display a wide variety of biological activities, from antimicrobial to antiallodynic …

Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature

PG Arnison, MJ Bibb, G Bierbaum, AA Bowers… - Natural product …, 2013 - pubs.rsc.org
Covering: 1988 to 2012 This review presents recommended nomenclature for the
biosynthesis of ribosomally synthesized and post-translationally modified peptides (RiPPs) …

New insights into the biosynthetic logic of ribosomally synthesized and post-translationally modified peptide natural products

MA Ortega, WA Van Der Donk - Cell chemical biology, 2016 - cell.com
Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a large
group of structurally diverse natural products. Their biological activities and unique …

Expansion of RiPP biosynthetic space through integration of pan-genomics and machine learning uncovers a novel class of lanthipeptides

AM Kloosterman, P Cimermancic, SS Elsayed… - PLoS …, 2020 - journals.plos.org
Microbial natural products constitute a wide variety of chemical compounds, many which can
have antibiotic, antiviral, or anticancer properties that make them interesting for clinical …

New Insights Into the Mechanisms and Biological Roles of D-Amino Acids in Complex Eco-Systems

A Aliashkevich, L Alvarez, F Cava - Frontiers in microbiology, 2018 - frontiersin.org
In the environment bacteria share their habitat with a great diversity of organisms, from
microbes to humans, animals and plants. In these complex communities, the production of …

Functional Genome Mining Reveals a Class V Lanthipeptide Containing a d‐Amino Acid Introduced by an F420H2‐Dependent Reductase

M Xu, F Zhang, Z Cheng, G Bashiri… - Angewandte Chemie …, 2020 - Wiley Online Library
Lantibiotics are a type of ribosomally synthesized and post‐translationally modified peptides
(termed lanthipeptides) with often potent antimicrobial activity. Herein, we report the …

Occurrence and dynamism of lactic acid bacteria in distinct ecological niches: a multifaceted functional health perspective

F George, C Daniel, M Thomas, E Singer… - Frontiers in …, 2018 - frontiersin.org
Lactic acid bacteria (LAB) are representative members of multiple ecosystems on earth,
displaying dynamic interactions within animal and plant kingdoms in respect with other …

Lantibiotics: peptides of diverse structure and function

JM Willey, WA Van Der Donk - Annu. Rev. Microbiol., 2007 - annualreviews.org
The current need for antibiotics with novel target molecules has coincided with advances in
technical approaches for the structural and functional analysis of the lantibiotics, which are …