Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they
control almost all aspects of a cell's life and death. These lipids gained tremendous research …

Lysosomes are key cellular catabolic centers that also perform fundamental metabolic,
signaling and quality control functions. Lysosomes are not static and they respond …

The retromer complex is a vital element of the endosomal protein sorting machinery that is
conserved across all eukaryotes. Retromer is most closely associated with the endosome-to …

Endocytosis marks the entry of internalized receptors into the complex network of endocytic
trafficking pathways. Endocytic vesicles are rapidly targeted to a distinct membrane-bound …

The Class III PI3K (phosphoinositide 3-kinase), Vps34 (vacuolar protein sorting 34), was first
described as a component of the vacuolar sorting system in Saccharomyces cerevisiae and …

The retromer complex mediates retrograde transport of transmembrane cargo from
endosomes to the trans-Golgi network (TGN). Mammalian retromer is composed of a sorting …

Sorting nexins are a large family of evolutionarily conserved phosphoinositide-binding
proteins that have fundamental roles in orchestrating cargo sorting through the membranous …

Retromer is a protein assembly that has a central role in endosomal trafficking, and retromer
dysfunction has been linked to a growing number of neurological disorders. First linked to …

The retromer is a heteropentameric complex that associates with the cytosolic face of
endosomes and mediates retrograde transport of transmembrane cargo from endosomes to …

Phox homology (PX) domains are membrane interacting domains that bind to
phosphatidylinositol phospholipids or phosphoinositides, markers of organelle identity in the …