Adult hepatocyte identity is constructed throughout embryonic development and fine-tuned
after birth. A multinodular network of transcription factors, along with pre-mRNA splicing …

Sustaining both proteome and genome integrity (GI) requires the integration of a wide range
of mechanisms and signaling pathways. These comprise, in particular, the unfolded protein …

Waddington's epigenetic landscape is a metaphor frequently used to illustrate cell
differentiation. Recent advances in single-cell genomics are altering our understanding of …

Disruption of alveolar type 2 cell (AEC2) protein quality control has been implicated in
chronic lung diseases, including pulmonary fibrosis (PF). We previously reported the in vivo …

Membrane-bound transcription factors (MTFs) are transcription factors (TFs) that are
anchored in membranes in a dormant state. Activated by external or internal stimuli, MTFs …

Hepatocytes synthesise the majority of serum proteins. This production occurs in the
endoplasmic reticulum (ER) and is adjusted by complex local and systemic regulatory …

The mechanism by which mammalian liver cell responses are coordinated during tissue
homeostasis and perturbation is poorly understood, representing a major obstacle in our …

Background & Aims Throughout life, the intestinal epithelium undergoes constant self-
renewal from intestinal stem cells. Together with genotoxic stressors and failing DNA repair …

Background & Aims N 6-methyladenosine (m 6 A), the most prevalent and dynamic
posttranscriptional methylation modification of mammalian mRNA, is involved in various …

Nowadays, the nutraceutical agent sulforaphane (SFN) shows great versatility in turning on
different cellular responses. Mainly, this isothiocyanate acts as a master regulator of cellular …