Rapid eye movement (REM) sleep behaviour disorder (RBD) is a parasomnia that is
characterized by loss of muscle atonia during REM sleep (known as REM sleep without …

Braak's hypothesis has been extremely influential over the last two decades. However,
neuropathological and clinical evidence suggest that the model does not conform to all …

Parkinson's disease varies widely in clinical manifestations, course of progression and
biomarker profiles from person to person. Identification of distinct Parkinson's disease …

Importance There is increasing evidence that Parkinson disease (PD) is heterogeneous in
its clinical presentation and prognosis. Defining subtypes of PD is needed to better …

Sleep disorders are among the most common non-motor manifestations in Parkinson's
disease (PD) and have a significant negative impact on quality of life. While sleep disorders …

Abstract Study Objectives Rapid eye movement (REM) sleep behavior disorder (RBD) is a
parasomnia associated with neurodegenerative synucleinopathies. Its prevalence is largely …

Methods We used Canadian and American national guidelines to inform this review, in
addition to published systematic reviews that were known to us. We identified additional …

Objective To assess whether risk factors for Parkinson disease and dementia with Lewy
bodies increase rate of defined neurodegenerative disease in idiopathic rapid eye …

Parkinson's disease (PD) is a common, progressive, and currently incurable
neurodegenerative movement disorder. The diagnosis of PD is challenging, especially in …

Objectives Rapid eye movement (REM) sleep behavior disorder (RBD) is the most specific
marker of prodromal alpha-synucleinopathies. We sought to delineate the baseline clinical …