Since May 2022, the mpox virus (MPXV) has spread worldwide and become a potential
threat to global public health. Vaccines are important tools for preventing MPXV …

Peptide-based vaccines offer several advantages over conventional whole organism or
protein approaches by offering improved purity and specificity in inducing immune response …

The influenza virus is a persistent burden on global health, with seasonal vaccines providing
incomplete protection. CD4+ T cells help shape B cell and antibody responses; however, the …

Tracking antigen-specific T cell responses over time within individuals is difficult because of
lack of knowledge of antigen-specific TCR sequences, limitations in sample size, and assay …

Many HIV-1-infected patients evolve broadly neutralizing antibodies (bnAbs). This
evolutionary process typically takes several years and is poorly understood as selection …

ABSTRACT The Epstein-Barr virus (EBV) gp350 glycoprotein interacts with the cellular
receptor to mediate viral entry and is thought to be the major target for neutralizing …

T cell priming is a critical event in the initiation of the immune response to vaccination since
it deeply influences both the magnitude and the quality of the immune response induced …

The development of new low cost inactivated polio virus based vaccines (IPV) is a high
priority, and will be required to eradicate polio. In addition, such a vaccine constitutes the …

Antigen-specific CD4+ T helper cell responses have long been recognized to be a critical
component of effective vaccine immunity. CD4+ T cells are necessary to generate and …

Chronic infections with non-cytopathic viruses constitutively expose virus-specific adaptive
immune cells to cognate antigen, requiring their numeric and functional adaptation. Virus …