Protein kinase C (PKC) has been a tantalizing target for drug discovery ever since it was first
identified as the receptor for the tumour promoter phorbol ester in 1982. Although initial …

The AGC family of serine/threonine kinases (PKA, PKG, PKC) includes more than 60
members that are critical regulators of numerous cellular functions, including cell cycle and …

Protein kinase C (PKC) isoforms comprise a family of lipid-activated enzymes that have
been implicated in a wide range of cellular functions. PKCs are modular enzymes comprised …

Members of the mammalian protein kinase C (PKC) superfamily play key regulatory roles in
a multitude of cellular processes, ranging from control of fundamental cell autonomous …

The discovery in the early 1980s that protein kinase C is 'the receptor'for the tumor-
promoting phorbol esters catapulted this enzyme to the forefront of research in signal …

Diabetes mellitus is a chronic disease caused by inherited and/or acquired deficiency in
production of insulin by the pancreas, and by resistance to insulin's effects. Such a …

Abstract The Receptor for Activated C Kinase 1 (RACK1) is a member of the tryptophan-
aspartate repeat (WD-repeat) family of proteins and shares significant homology to the β …

Vascular smooth muscle (VSM) plays an important role in the regulation of vascular function.
Identifying the mechanisms of VSM contraction has been a major research goal in order to …

Protein kinase C has been in the spotlight since the discovery two decades ago that is
activated by the lipid second messenger diacylglycerol. Despite protein kinase C's enduring …

Conflicting roles for protein kinase C (PKC) isozymes in cardiac disease have been
reported. Here, δPKC-selective activator and inhibitor peptides were designed rationally …