Engineering Anisotropy into Organized Nanoscale Matter

W Zhou, Y Li, BE Partridge, CA Mirkin - Chemical Reviews, 2024 - ACS Publications
Programming the organization of discrete building blocks into periodic and quasi-periodic
arrays is challenging. Methods for organizing materials are particularly important at the …

Programmability and biomedical utility of intrinsically-disordered protein polymers

MC Giraldo-Castano, KA Littlejohn… - Advanced Drug Delivery …, 2024 - Elsevier
Intrinsically disordered proteins (IDPs) exhibit molecular-level conformational dynamics that
are functionally harnessed across a wide range of fascinating biological phenomena. The …

Proteininvbench: Benchmarking protein inverse folding on diverse tasks, models, and metrics

Z Gao, C Tan, Y Zhang, X Chen… - Advances in Neural …, 2024 - proceedings.neurips.cc
Protein inverse folding has attracted increasing attention in recent years. However, we
observe that current methods are usually limited to the CATH dataset and the recovery …

De novo design of allosterically switchable protein assemblies

A Pillai, A Idris, A Philomin, C Weidle, R Skotheim… - Nature, 2024 - nature.com
Allosteric modulation of protein function, wherein the binding of an effector to a protein
triggers conformational changes at distant functional sites, plays a central part in the control …

Peptide bundlemer networks or lattices: controlling cross-linking and self-assembly using protein-like display of chemistry

AL McCahill, T Zhang, JG Saven, CJ Kloxin… - ACS …, 2024 - ACS Publications
Coiled-coil 'bundlemer'peptides were selectively modified with allyloxycarbonyl (alloc)-
protected lysine, a non-natural amino acid containing an alkene on its side chain. The …

Blueprinting extendable nanomaterials with standardized protein blocks

TF Huddy, Y Hsia, RD Kibler, J Xu, N Bethel… - Nature, 2024 - nature.com
A wooden house frame consists of many different lumber pieces, but because of the
regularity of these building blocks, the structure can be designed using straightforward …

AlphaFold 3–Aided Design of DNA Motifs To Assemble into Triangles

Anusha, Z Zhang, J Li, H Zuo… - Journal of the American …, 2024 - ACS Publications
Self-assembly of biomolecules provides a powerful tool for a wide range of applications in
nanomedicine, biosensing and imaging, vaccines, computation, nanophotonics, etc. The key …

Beyond 25 years of biomedical innovation in nano-bioelectronics

P Li, S Kim, B Tian - Device, 2024 - cell.com
Nano-bioelectronics, which blend the precision of nanotechnology with the complexity of
biological systems, are evolving with innovations such as silicon nanowires, carbon …

Biopharmaceutical drug delivery and phototherapy using protein crystals

R Zhou, J Qu, X Liu, F Lin, TY Ohulchanskyy… - Advanced Drug Delivery …, 2024 - Elsevier
Biopharmaceutical drugs, including proteins, peptides, and antibodies, are renowned for
their high specificity and efficacy, fundamentally transforming disease treatment paradigms …

Nanoparticle Superlattices with Nonequilibrium Crystal Shapes

M Ye, T Hueckel, PP Gatenil, K Nagao, WC Carter… - ACS …, 2024 - ACS Publications
Nanoparticle assembly is a material synthesis strategy that enables precise control of
nanoscale structural features. Concepts from traditional crystal growth research have been …