Ion channels in microbes
B Martinac, Y Saimi, C Kung - Physiological reviews, 2008 - journals.physiology.org
Studies of ion channels have for long been dominated by the animalcentric, if not
anthropocentric, view of physiology. The structures and activities of ion channels had …
anthropocentric, view of physiology. The structures and activities of ion channels had …
Static light scattering to characterize membrane proteins in detergent solution
DJ Slotboom, RH Duurkens, K Olieman, GB Erkens - Methods, 2008 - Elsevier
Determination of the oligomeric state or the subunit stoichiometry of integral membrane
proteins in detergent solution is notoriously difficult, because the amount of detergent (and …
proteins in detergent solution is notoriously difficult, because the amount of detergent (and …
[HTML][HTML] Piezo1 channels are inherently mechanosensitive
The conversion of mechanical force to chemical signals is critical for many biological
processes, including the senses of touch, pain, and hearing. Mechanosensitive ion channels …
processes, including the senses of touch, pain, and hearing. Mechanosensitive ion channels …
[HTML][HTML] Molecular basis of force-from-lipids gating in the mechanosensitive channel MscS
Prokaryotic mechanosensitive (MS) channels open by sensing the physical state of the
membrane. As such, lipid-protein interactions represent the defining molecular process …
membrane. As such, lipid-protein interactions represent the defining molecular process …
Differential effects of lipids and lyso-lipids on the mechanosensitivity of the mechanosensitive channels MscL and MscS
Mechanosensitive (MS) channels of small (MscS) and large (MscL) conductance are the
major players in the protection of bacterial cells against hypoosmotic shock. Although a …
major players in the protection of bacterial cells against hypoosmotic shock. Although a …
A structural mechanism for MscS gating in lipid bilayers
The mechanosensitive channel of small conductance (MscS) is a key determinant in the
prokaryotic response to osmotic challenges. We determined the structural rearrangements …
prokaryotic response to osmotic challenges. We determined the structural rearrangements …
[HTML][HTML] Selectivity mechanism of the mechanosensitive channel MscS revealed by probing channel subconducting states
The mechanosensitive channel of small conductance (MscS) has been characterized at both
functional and structural levels and has an integral role in the protection of bacterial cells …
functional and structural levels and has an integral role in the protection of bacterial cells …
[HTML][HTML] Membrane stiffness is one of the key determinants of E. coli MscS channel mechanosensitivity
Mechanosensitive (MS) channels have an intimate relationship with membrane lipids that
underlie their mechanosensitivity. Membrane lipids may influence channel activity by directly …
underlie their mechanosensitivity. Membrane lipids may influence channel activity by directly …
[HTML][HTML] Structural dynamics of an isolated voltage-sensor domain in a lipid bilayer
A strong interplay between the voltage-sensor domain (VSD) and the pore domain (PD)
underlies voltage-gated channel functions. In a few voltage-sensitive proteins, the VSD has …
underlies voltage-gated channel functions. In a few voltage-sensitive proteins, the VSD has …
Three-dimensional architecture of membrane-embedded MscS in the closed conformation
The mechanosensitive channel of small conductance (MscS) is part of a coordinated
response to osmotic challenges in Escherichia coli. MscS opens as a result of membrane …
response to osmotic challenges in Escherichia coli. MscS opens as a result of membrane …