In recent years, a number of studies focused on the role of epigenetics, including DNA
methylation, in spermatogenesis and male infertility. We aimed to provide an overview of the …

The epigenetic profile of germ cells, which is defined by modifications of DNA and
chromatin, changes dynamically during their development. Many of the changes are …

Protamines are the major nuclear sperm proteins. The human sperm nucleus contains two
types of protamine: protamine 1 (P1) encoded by a single-copy gene and the family of …

A key step in many chromatin-related processes is the recognition of histone post-
translational modifications by effector modules such as bromodomains and chromo-like …

Increasing attention has focused on the significance of RNA in sperm, in light of its
contribution to the birth and long-term health of a child, role in sperm function and diagnostic …

Epigenetic modifications characterized by DNA methylation, histone modifications, and
chromatin remodeling are important regulators in a number of biological processes …

Folates belong to the vitamin B group and are involved in a large number of biochemical
processes, particularly in the metabolism of homocysteine. Dietary or genetically determined …

OBJECTIVE: To evaluate the associations between proper protamine incorporation and
DNA methylation at imprinted loci. DESIGN: Experimental research study. SETTING …

Male infertility is a common and complex problem affecting 1 in 20 men. Despite voluminous
research in this field, in many cases, the underlying causes are unknown. Epigenetic factors …

Background Male-factor infertility is a common condition, and etiology is unknown for a high
proportion of cases. Abnormal epigenetic programming of the germline is proposed as a …