Post-translational modification (PTM) of proteins allows cells to regulate protein functions,
transduce signals and respond to perturbations. PTMs expand protein functionality and …

Abstract EGLN1, EGLN2 and EGLN3 are proline hydroxylase whose main function is the
regulation of the HIF factors. They work as oxygen sensors and are the main responsible of …

Phosphorylation is a major constituent of the CTD code, which describes the set of post-
translational modifications on 52 repeats of a YSPTSPS consensus heptad that orchestrates …

In eukaryotic nuclei, most genes are transcribed by RNA polymerase II (RNAP2), whose
regulation is a key to understanding the genome and cell function. RNAP2 has a long …

The Rpd3S histone deacetylase complex has a crucial role in genomic integrity by
deacetylating transcribed nucleosomes following RNA polymerase (Pol) II passage. Cryo …

The C-terminal domain of RPB1 (CTD) orchestrates transcription by recruiting regulators to
RNA Pol II upon phosphorylation. With CTD driving condensate formation on gene loci, the …

Summary Cyclin-dependent kinase 7 (CDK7), part of the general transcription factor TFIIH,
promotes gene transcription by phosphorylating the C-terminal domain of RNA polymerase …

Post-translational modifications (PTMs) fine-tune various signaling pathways not only by the
modification of a single residue, but also by the interplay of different modifications on residue …

In eukaryotes, RNA polymerase II (Pol II) is responsible for the synthesis of all mRNAs and
myriads of short and long untranslated RNAs, whose fabrication involves close …

While the biochemistry of gene transcription has been well studied, our understanding of
how this process is organised in 3D within the intact nucleus is less well understood. Here …