The production of therapeutic proteins in mammalian cell culture is an essential unit
operation in biopharmaceutical manufacture that can benefit from the predictive insights of …

The variation of antigen binding sites on monoclonal antibodies (mAbs) enables
manufacturing of the latter for targeted treatment of a variety of ailments, including cancer …

This article demonstrates a parameter estimation technique for bioprocesses that utilizes
measurement noise in experimental data to determine credible intervals on parameter …

This work proposes an original sequential parameter identification method of a dynamic
model of Escherichia coli BL21 (DE3) fed-batch cultures. The proposed macroscopic model …

In this study, a dynamic model of a Vero cell culture‐based dengue vaccine production
process is developed. The approach consists in describing the process dynamics as …

Efficient network inference is one of the challenges of current-day biology. Its application to
the study of development has seen noteworthy success, yet a multicellular context, tissue …

The production of therapeutic proteins in mammalian cell culture is an essential unit
operation in biopharmaceutical manufacture that can benefit from the predictive insights of …

In this thesis we propose a new method for the parameter identification of large-scale
models. The proposed state substitution method can be applied to parametric, non …

Die Produktion biopharmazeutischer Glykoproteine erfolgt häufig durch die Kultivierung
gentechnisch veränderter Säugetierzellen. Zu Beginn eines Produktionsprozesses wird eine …

The ability to identify the parameters of models of complex large-scale (bio) chemical
systems is critical as this allows an understanding of a system as well the use of the model …