Convection-enhanced delivery (CED) is a bulk flow–driven process. Its properties permit
direct, homogeneous, targeted perfusion of CNS regions with putative therapeutics while …

Brain perturbation studies allow detailed causal inferences of behavioral and neural
processes. Because the combination of brain perturbation methods and neural …

During decision making, neurons in multiple brain regions exhibit responses that are
correlated with decisions,,,,,. However, it remains uncertain whether or not various forms of …

Neocortical epilepsy is frequently drug-resistant. Surgery to remove the epileptogenic zone
is only feasible in a minority of cases, leaving many patients without an effective treatment …

Epilepsies are common chronic neurological diseases characterized by recurrent
unprovoked seizures of central origin. The mainstay of treatment involves symptomatic …

Huntington disease is an autosomal dominant neurodegenerative disorder caused by a
toxic expansion in the CAG repeat region of the huntingtin gene. Oligonucleotide …

Huntington's disease is an autosomal dominant neurodegenerative disease caused by a
toxic gain of function mutation in the huntingtin gene (Htt). Silencing of Htt with RNA …

One of the challenges in treating central nervous system (CNS) disorders with biomolecules
is achieving local delivery while minimizing invasiveness. For the treatment of stroke …

Convection-enhanced delivery (CED) is a technique designed to deliver drugs directly into
the brain or tumors. Its ability to bypass the blood-brain barrier (BBB), one of the major …

Lesions in human posterior parietal cortex can cause optic ataxia (OA), in which reaches but
not saccades to visual objects are impaired, suggesting separate visuomotor pathways for …