BACKGROUND A normal chromosomal constitution defined through PGT-A assessing all
chromosomes on trophectoderm (TE) biopsies represents the strongest predictor of embryo …

BACKGROUND Although laboratory procedures, along with culture media formulations,
have improved over the past two decades, the issue remains that human IVF is performed in …

BACKGROUND The advances in the world of IVF during the last decades have been rapid
and impressive and culture media play a major role in this success. Until the 1980s fertility …

BACKGROUND Transfer of more than a single embryo in an IVF cycle comes with the finite
possibility of a multiple gestation. Even a twin pregnancy confers significant risk to both …

BACKGROUND Successful embryo implantation is a complex process that requires the
coordination of a series of events, involving both the embryo and the maternal endometrium …

Mitochondria, originally of bacterial origin, are highly dynamic organelles that have evolved
a symbiotic relationship within eukaryotic cells. Mitochondria undergo dynamic, stage …

The mitochondria, present in almost all eukaryotic cells, produce energy but also contribute
to many other essential cellular functions. One of the unique characteristics of the …

The mammalian blastocyst exhibits an idiosyncratic metabolism, reflecting its unique
physiology and its ability to undergo implantation. Glucose is the primary nutrient of the …

The mammalian blastocyst exhibits a high capacity for aerobic glycolysis, a metabolic
characteristic of tumours. It has been considered that aerobic glycolysis is a means to …

The phenotype of the human embryo conceived through in vitro fertilization (IVF), that is its
morphology, developmental kinetics, physiology and metabolism, can be affected by …