Protein misfolding is prominent in early cellular pathology of Alzheimer's disease (AD),
implicating pathophysiological significance of endoplasmic reticulum stress/unfolded protein …

Ca2+ signaling is ubiquitous in eukaryotic cells and modulates many cellular events
including cell migration. Directional cell migration requires the polarization of both signaling …

Colorectal carcinoma (CRC) represents the fourth most common cancer worldwide and is
the third most common cause of malignancy-associated mortality. Distant metastases to the …

In non-excitable cells, Orai proteins represent the main channel for Store-Operated Calcium
Entry (SOCE), and also mediate various store-independent Calcium Entry (SICE) pathways …

Nitric oxide (NO) represents a crucial mediator to regulate cerebral blood flow (CBF) in the
human brain both under basal conditions and in response to somatosensory stimulation. An …

Cytosolic Ca2+ signals are organized in complex spatial and temporal patterns that underlie
their unique ability to regulate multiple cellular functions. Changes in intracellular Ca2+ …

Background: Colorectal cancer (CRC) is a highly devastating cancer. Ca2+-dependent
channels are now considered key regulators of tumor progression. In this study, we aimed to …

Nicotinic acid adenine dinucleotide phosphate (NAADP) gates two-pore channels 1 and 2
(TPC1 and TPC2) to elicit endo-lysosomal (EL) Ca2+ release. NAADP-induced EL Ca2+ …

Solid tumours are characterised by an altered microenvironment (TME) from the
physicochemical point of view, displaying a highly hypoxic and acidic interstitial fluid …

Second trimester foetal human amniotic fluid‐derived stem cells (hAFS) have been shown to
possess remarkable cardioprotective paracrine potential in different preclinical models of …