The neuroprotective effects of glucagon-like peptide 1 in Alzheimer's and Parkinson's disease: An in-depth review

N Reich, C Hölscher - Frontiers in neuroscience, 2022 - frontiersin.org
Currently, there is no disease-modifying treatment available for Alzheimer's and Parkinson's
disease (AD and PD) and that includes the highly controversial approval of the Aβ-targeting …

[HTML][HTML] Into the groove: can rhythm influence Parkinson's disease?

C Nombela, LE Hughes, AM Owen, JA Grahn - … & Biobehavioral Reviews, 2013 - Elsevier
Previous research has noted that music can improve gait in several pathological conditions,
including Parkinson's disease, Huntington's disease and stroke. Current research into …

Glycolytic metabolism, brain resilience, and Alzheimer's disease

X Zhang, N Alshakhshir, L Zhao - Frontiers in Neuroscience, 2021 - frontiersin.org
Alzheimer's disease (AD) is the most common form of age-related dementia. Despite
decades of research, the etiology and pathogenesis of AD are not well understood. Brain …

Roles of amyloid β-peptide-associated oxidative stress and brain protein modifications in the pathogenesis of Alzheimer's disease and mild cognitive impairment

DA Butterfield, T Reed, SF Newman… - Free Radical Biology and …, 2007 - Elsevier
Oxidative stress has been implicated to play a crucial role in the pathogenesis of a number
of diseases, including neurodegenerative disorders, cancer, and ischemia, just to name a …

New insights into an old protein: the functional diversity of mammalian glyceraldehyde-3-phosphate dehydrogenase

MA Sirover - Biochimica et Biophysica Acta (BBA)-Protein Structure …, 1999 - Elsevier
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was considered a classical
glycolytic protein examined for its pivotal role in energy production. It was also used as a …

Glyceraldehyde-3-phosphate dehydrogenase, apoptosis, and neurodegenerative diseases

DM Chuang, C Hough… - Annu. Rev. Pharmacol …, 2005 - annualreviews.org
▪ Abstract Increasing evidence supports the notion that glyceraldehyde-3-phosphate
dehydrogenase (GAPDH) is a protein with multiple functions, including its surprising role in …

Excitotoxic neuronal death and the pathogenesis of Huntington's disease

AME Sánchez, J Mejía-Toiber, L Massieu - Archives of medical research, 2008 - Elsevier
Huntington's disease (HD) is a neurodegenerative hereditary illness originated by the
mutation of the gene encoding the huntingtin-protein (htt). Mutated htt (mhtt) is characterized …

Neurotoxicity of advanced glycation end-products for cultured cortical neurons

M Takeuchi, R Bucala, T Suzuki… - … of Neuropathology & …, 2000 - academic.oup.com
The Maillard reaction that leads to the formation of advanced glycation end-products (AGEs)
plays an important role in the pathogenesis of angiopathy in diabetic patients and in aging …

[HTML][HTML] GAPDH as a sensor of NO stress

MR Hara, MB Cascio, A Sawa - … et Biophysica Acta (BBA)-Molecular Basis …, 2006 - Elsevier
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a classic glycolytic enzyme, and
accumulating evidence has suggested that GAPDH is a multi-functional protein. In particular …

The triangle of death in Alzheimer's disease brain: the aberrant cross-talk among energy metabolism, mammalian target of rapamycin signaling, and protein …

F Di Domenico, E Barone, M Perluigi… - Antioxidants & redox …, 2017 - liebertpub.com
Significance: Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder and
represents one of the most disabling conditions. AD shares many features in common with …