The diverse roles of arrestin scaffolds in G protein–coupled receptor signaling
YK Peterson, LM Luttrell - Pharmacological reviews, 2017 - ASPET
The visual/β-arrestins, a small family of proteins originally described for their role in the
desensitization and intracellular trafficking of G protein–coupled receptors (GPCRs), have …
desensitization and intracellular trafficking of G protein–coupled receptors (GPCRs), have …
All roads lead to PP 2A: exploiting the therapeutic potential of this phosphatase
J Sangodkar, CC Farrington, K McClinch… - The FEBS …, 2016 - Wiley Online Library
Protein phosphatase 2A (PP 2A) is a serine/threonine phosphatase involved in the
regulation of many cellular processes. A confirmed tumor suppressor protein, PP 2A is …
regulation of many cellular processes. A confirmed tumor suppressor protein, PP 2A is …
[HTML][HTML] The role of APOBEC3B in lung tumor evolution and targeted cancer therapy resistance
In this study, the impact of the apolipoprotein B mRNA-editing catalytic subunit-like
(APOBEC) enzyme APOBEC3B (A3B) on epidermal growth factor receptor (EGFR)-driven …
(APOBEC) enzyme APOBEC3B (A3B) on epidermal growth factor receptor (EGFR)-driven …
Identification of Integrator-PP2A complex (INTAC), an RNA polymerase II phosphatase
INTRODUCTION RNA cleavage and phosphorylation-dephosphorylation of the RNA
polymerase II (Pol II) C-terminal domain (CTD) are two regulatory mechanisms of …
polymerase II (Pol II) C-terminal domain (CTD) are two regulatory mechanisms of …
The ERK pathway: molecular mechanisms and treatment of depression
JQ Wang, L Mao - Molecular neurobiology, 2019 - Springer
Major depressive disorder is a chronic debilitating mental illness. Its pathophysiology at
cellular and molecular levels is incompletely understood. Increasing evidence supports a …
cellular and molecular levels is incompletely understood. Increasing evidence supports a …
[HTML][HTML] From promiscuity to precision: protein phosphatases get a makeover
DM Virshup, S Shenolikar - Molecular cell, 2009 - cell.com
The control of biological events requires strict regulation using complex protein
phosphorylation and dephosphorylation strategies. The bulk of serine-threonine …
phosphorylation and dephosphorylation strategies. The bulk of serine-threonine …
Phosphatase‐mediated crosstalk between MAPK signaling pathways in the regulation of cell survival
MR Junttila, SP Li, J Westermarck - The FASEB Journal, 2008 - Wiley Online Library
Mitogen‐activated protein kinase (MAPK) pathways constitute a large modular network that
regulates a variety of physiological processes, such as cell growth, differentiation, and …
regulates a variety of physiological processes, such as cell growth, differentiation, and …
Protein phosphatase 2A regulatory subunits and cancer
PJA Eichhorn, MP Creyghton, R Bernards - Biochimica et Biophysica Acta …, 2009 - Elsevier
The serine/threonine protein phosphatase (PP2A) is a trimeric holoenzyme that plays an
integral role in the regulation of a number of major signaling pathways whose deregulation …
integral role in the regulation of a number of major signaling pathways whose deregulation …
Loss of GluN2B-containing NMDA receptors in CA1 hippocampus and cortex impairs long-term depression, reduces dendritic spine density, and disrupts learning
JL Brigman, T Wright, G Talani… - Journal of …, 2010 - Soc Neuroscience
NMDA receptors (NMDARs) are key mediators of certain forms of synaptic plasticity and
learning. NMDAR complexes are heteromers composed of an obligatory GluN1 subunit and …
learning. NMDAR complexes are heteromers composed of an obligatory GluN1 subunit and …
The life cycle of C-myc: from synthesis to degradation
RC Sears - Cell cycle, 2004 - Taylor & Francis
The c-Myc transcription factor is a potent regulator of cellular proliferation and cell fate
decision. Precise regulation of c-Myc protein levels is essential to maintain normal cell …
decision. Precise regulation of c-Myc protein levels is essential to maintain normal cell …