Epilepsy is the third most common chronic brain disorder, and is characterized by an
enduring predisposition to generate seizures. Despite progress in pharmacological and …

Despite the introduction of over 15 third-generation anti-epileptic drugs, current medications
fail to control seizures in 20–30% of patients. However, our understanding of the …

Ionic currents and the network-driven patterns they generate differ in immature and adult
neurons: The developing brain is not a “small adult brain.” One of the most investigated …

The third edition of the hugely successful Handbook of Child and Adolescent Clinical
Psychology incorporates important advances in the field to provide a reliable and accessible …

The diagnosis, evaluation, and management of infantile spasms (IS) continue to pose
significant challenges to the treating physician. Although an evidence‐based practice …

This document provides guidance on the use of valproate in girls and women of
childbearing age from a joint Task Force of the Commission on European Affairs of the …

Lennox-Gastaut syndrome is one of the most severe epileptic encephalopathies of
childhood onset. The cause of this syndrome can be symptomatic (ie, secondary to an …

Lennox–Gastaut syndrome (LGS) is a severe epileptic and developmental encephalopathy
that is associated with a high rate of morbidity and mortality. It is characterized by multiple …

A big advance in epileptology has been the recognition of syndromes with distinct aetiology,
clinical and EEG features, treatment and prognosis. A prime and common example of this is …

The current spectrum of disorders associated to clinical spasms with onset in infancy is
wider than previously thought; accordingly, its terminology has changed. Nowadays, the …