More than one-third of the worldwide population is overweight or obese and therefore at risk
of developing type 2 diabetes mellitus. In order to mitigate this pandemic, safer and more …

The worldwide upward trend in obesity has been dramatic, now affecting more than 20% of
American women of reproductive age. Obesity is associated with many adverse maternal …

Inheritance of genomic DNA underlies the vast majority of biological inheritance, yet it has
been clear for decades that additional epigenetic information can be passed on to future …

There is considerable controversy regarding epigenetic inheritance in mammalian gametes.
Using in vitro fertilization to ensure exclusive inheritance via the gametes, we show that a …

It has long been understood that the pathogenesis of complex diseases such as diabetes
includes both genetic and environmental components. More recently, it has become clear …

A variety of experimental and epidemiological studies lend support to the Developmental
Origin of Health and Disease (DOHaD) concept. Yet, the actual mechanisms accounting for …

Mammalian oocytes and early cleavage-stage embryos are critically dependent on their~
100,000 mitochondria to develop from ovulation to compacted morula stage. They rely …

The American Diabetes Association convened a research symposium,“Epigenetics and
Epigenomics: Implications for Diabetes and Obesity” on 17–19 November 2017 …

Size at birth is a critical determinant of life expectancy, and is dependent primarily on the
placental supply of nutrients. However, the placenta is not just a passive organ for the …

The placenta is the main determinant of fetal growth and development in utero. It supplies all
the nutrients and oxygen required for fetal growth and secretes hormones that facilitate …