Chronic migraine is a disabling neurological disorder that imposes a considerable burden
on individual and socioeconomic outcomes. Chronic migraine is defined as headaches …

Globally, migraine is a leading cause of disability with a huge impact on both the work and
private life of affected persons. To overcome the societal migraine burden, better treatment …

Migraine is one of the most disabling and prevalent of all disorders. To improve
understanding of migraine mechanisms and to suggest a new therapeutic target, we …

Importance Vasoactive intestinal polypeptide (VIP) and pituitary adenylate cyclase-activating
polypeptides (PACAPs) are structurally and functionally related, yet different in their …

Background Knowledge of exact signalling events during migraine attacks is lacking.
Various substances are known to trigger migraine attacks in patients and calcitonin gene …

Background Recent discovery of mechanosensitive Piezo receptors in trigeminal ganglia
suggested the novel molecular candidate for generation of migraine pain. However, the …

Background Recently, the adenosine triphosphate (ATP) sensitive potassium channel
opener levcromakalim was shown to induce migraine attacks with a far higher incidence …

Migraine is a primary headache disorder ranked as the leading cause of years lived with
disability among individuals younger than 50 years. The aetiology of migraine is complex …

Background Calcitonin gene-related peptide release in trigeminovascular system is a pivotal
component of neurogenic inflammation underlying migraine pathophysiology. Transient …

Background ATP‐sensitive potassium (KATP) channel opener levcromakalim induces
migraine attacks in migraine patients. Underlying mechanisms responsible for headache …