From pregnancy to preeclampsia: a key role for estrogens
Preeclampsia (PE) results in placental dysfunction and is one of the primary causes of
maternal and fetal mortality and morbidity. During pregnancy, estrogen is produced primarily …
maternal and fetal mortality and morbidity. During pregnancy, estrogen is produced primarily …
Molecular mechanisms involved in the regulation of the endothelial nitric oxide synthase
I Fleming, R Busse - American Journal of Physiology …, 2003 - journals.physiology.org
The endothelial nitric oxide synthase (eNOS), the expression of which is regulated by a
range of transcriptional and posttranscriptional mechanisms, generates nitric oxide (NO) in …
range of transcriptional and posttranscriptional mechanisms, generates nitric oxide (NO) in …
Gender, sex hormones, and vascular tone
JM Orshal, RA Khalil - American Journal of Physiology …, 2004 - journals.physiology.org
The greater incidence of hypertension and coronary artery disease in men and
postmenopausal women compared with premenopausal women has been related, in part, to …
postmenopausal women compared with premenopausal women has been related, in part, to …
Evidence for altered placental blood flow and vascularity in compromised pregnancies
The placenta is the organ that transports nutrients, respiratory gases, and wastes between
the maternal and fetal systems. Consequently, placental blood flow and vascular …
the maternal and fetal systems. Consequently, placental blood flow and vascular …
Gender-based research underscores sex differences in biological processes, clinical disorders and pharmacological interventions
SR Bernstein, C Kelleher, RA Khalil - Biochemical Pharmacology, 2023 - Elsevier
Earlier research has presumed that the male and female biology is similar in most organs
except the reproductive system, leading to major misconceptions in research interpretations …
except the reproductive system, leading to major misconceptions in research interpretations …
Possible mechanisms underlying pregnancy-induced changes in uterine artery endothelial function
The last 10 years has seen a dramatic increase in our understanding of the mechanisms
underlying the pregnancy-specific adaptation in cardiovascular function in general and the …
underlying the pregnancy-specific adaptation in cardiovascular function in general and the …
Uteroplacental circulation in normal pregnancy and preeclampsia: functional adaptation and maladaptation
Uteroplacental blood flow increases as pregnancy advances. Adequate supply of nutrients
and oxygen carried by uteroplacental blood flow is essential for the well-being of the mother …
and oxygen carried by uteroplacental blood flow is essential for the well-being of the mother …
Gender differences in artery wall biomechanical properties throughout life
P Rossi, Y Francès, BA Kingwell… - Journal of …, 2011 - journals.lww.com
Elevated large artery stiffness and pulse pressure have emerged as important risk factors for
cardiovascular disease. The genders differ in large artery biomechanical properties …
cardiovascular disease. The genders differ in large artery biomechanical properties …
[HTML][HTML] Uterine vascular control preconception and during pregnancy
SB Fournier, JN D'Errico… - Comprehensive Physiology, 2021 - ncbi.nlm.nih.gov
Successful pregnancy and reproduction are dependent on adequate uterine blood flow,
placental perfusion, and vascular responsivity to fetal demands. The ability to support …
placental perfusion, and vascular responsivity to fetal demands. The ability to support …
Gender differences in the regulation of vascular tone
J Thompson, RA Khalil - Clinical and experimental …, 2003 - Wiley Online Library
The greater incidence of hypertension and coronary artery disease in men and post‐
menopausal women compared with premenopausal women has suggested vascular …
menopausal women compared with premenopausal women has suggested vascular …