Methylation at DNA, RNA and protein levels plays critical roles in many cellular processes
and is associated with diverse differentiation events, physiological activities and human …

Methylated lysine and arginine residues in histones represent a crucial part of the histone
code, and recognition of these methylated residues by protein interaction domains …

Biomolecular mass spectrometry has matured strongly over the past decades and has now
reached a stage where it can provide deep insights into the structure and composition of …

Quantitative information about the levels and dynamics of post-translational modifications
(PTMs) is critical for an understanding of cellular functions. Protein arginine methylation …

Internal methylation of eukaryotic mRNAs in the form of N6‐methyladenosine (m6A) and 5‐
methylcytidine (m5C) has long been known to exist, but progress in understanding its role …

The 25S rRNA of yeast contains several base modifications in the functionally important
regions. The enzymes responsible for most of these base modifications remained unknown …

Protein methylation plays an integral role in cellular signaling, most notably by modulating
proteins bound at chromatin and increasingly through regulation of non-histone proteins …

The existence of SpoU-TrmD (SPOUT) RNA methyltransferase superfamily was first
predicted by bioinformatics. SpoU is the previous name of TrmH, which catalyzes the 2'-O …

Ribosomes synthesize protein in all cells. Maintaining both the correct number and
composition of ribosomes is critical for protein homeostasis. To address this challenge, cells …

Arginine methylation is a common posttranslational modification with reported functions in
transcription, RNA processing and translation, and DNA repair. Trypanosomes encode five …