Fostamatinib for the treatment of adult persistent and chronic immune thrombocytopenia: results of two phase 3, randomized, placebo‐controlled trials

J Bussel, DM Arnold, E Grossbard… - American journal of …, 2018 - Wiley Online Library
Spleen tyrosine kinase (Syk) signaling is central to phagocytosis‐based, antibody‐mediated
platelet destruction in adults with immune thrombocytopenia (ITP). Fostamatinib, an oral Syk …

[HTML][HTML] First-line therapy for immune thrombocytopenia

S Mithoowani, DM Arnold - Hämostaseologie, 2019 - thieme-connect.com
Immune thrombocytopenia (ITP) is an autoimmune disease affecting blood platelets that
causes thrombocytopenia and an increased risk of bleeding. First-line therapy is indicated …

Primary and secondary immune cytopenias: evaluation and treatment approach in children

TO Kim, JM Despotovic - Hematology/Oncology Clinics, 2019 - hemonc.theclinics.com
Autoimmune cytopenias include autoimmune hemolytic anemia (AIHA), immune
thrombocytopenia (ITP), and autoimmune neutropenia (AIN), as well as rarer multilineage …

Second‐line treatments in children with immune thrombocytopenia: effect on platelet count and patient‐centered outcomes

RF Grace, KA Shimano, R Bhat… - American journal of …, 2019 - Wiley Online Library
Immune thrombocytopenia (ITP) is an autoimmune bleeding disorder with isolated
thrombocytopenia and hemorrhagic risk. While many children with ITP can be safely …

Fatigue in children and adolescents with immune thrombocytopenia

RF Grace, RJ Klaassen, KA Shimano… - British Journal of …, 2020 - Wiley Online Library
Immune thrombocytopenia (ITP), an acquired autoimmune disorder of low platelets and risk
of bleeding, has a substantial impact on health‐related quality of life (HRQoL). Patients with …

[HTML][HTML] Romiplostim in children with newly diagnosed or persistent primary immune thrombocytopenia

JD Grainger, T Kühne, J Hippenmeyer, N Cooper - Annals of Hematology, 2021 - Springer
Immune thrombocytopenia (ITP) is a disease of heterogenous origin characterized by low
platelet counts and an increased bleeding tendency. Three disease phases have been …

Thrombopoietin receptor agonists and rituximab for treatment of pediatric immune thrombocytopenia: a systematic review and meta‐analysis of prospective clinical …

N Ayad, RF Grace, H Al‐Samkari - Pediatric Blood & Cancer, 2022 - Wiley Online Library
Background Children with immune thrombocytopenia (ITP) may require second‐line ITP
therapies. The high remission rate in pediatric patients, need for extended‐duration use of …

The role of romiplostim for pediatric patients with immune thrombocytopenia

H Al-Samkari, RF Grace… - Therapeutic advances in …, 2020 - journals.sagepub.com
The thrombopoietin receptor agonists (TPO-RAs) are a class of platelet growth factors used
to treat immune thrombocytopenia (ITP) in children and adults. Romiplostim is a peptide …

[HTML][HTML] Psychometric evaluation of ITP life quality index (ILQI) in a global survey of patients with immune thrombocytopenia

R Viana, D D'Alessio, L Grant, N Cooper, D Arnold… - Advances in …, 2021 - Springer
Introduction Immune thrombocytopenia (ITP) is an autoimmune disorder caused by
immunologic destruction of otherwise normal platelets. Patients and physicians differ in their …

The incidence and clinical burden of immune thrombocytopenia in pediatric patients in the United States

J Shaw, K Kilpatrick, M Eisen, M Tarantino - Platelets, 2020 - Taylor & Francis
Immune thrombocytopenia (ITP) is the most common bleeding disorder diagnosed in
children. Characterized by low platelet counts, it leads to reduced clotting abilities and an …