Epithelial–mesenchymal transition programs and cancer stem cell phenotypes: mediators of breast cancer therapy resistance
AJ Gooding, WP Schiemann - Molecular Cancer Research, 2020 - AACR
Epithelial–mesenchymal transition (EMT) programs play essential functions in normal
morphogenesis and organogenesis, including that occurring during mammary gland …
morphogenesis and organogenesis, including that occurring during mammary gland …
Progesterone receptor signaling mechanisms
Progesterone receptor (PR) is a master regulator in female reproductive tissues that controls
developmental processes and proliferation and differentiation during the reproductive cycle …
developmental processes and proliferation and differentiation during the reproductive cycle …
Membrane-initiated estrogen, androgen, and progesterone receptor signaling in health and disease
Rapid effects of steroid hormones were discovered in the early 1950s, but the subject was
dominated in the 1970s by discoveries of estradiol and progesterone stimulating protein …
dominated in the 1970s by discoveries of estradiol and progesterone stimulating protein …
[HTML][HTML] Progesterone action in breast, uterine, and ovarian cancers
Progesterone and progesterone receptors (PRs) are essential for the development and
cyclical regulation of hormone-responsive tissues including the breast and reproductive …
cyclical regulation of hormone-responsive tissues including the breast and reproductive …
Deciphering the divergent roles of progestogens in breast cancer
Most breast cancers are driven by oestrogen receptor-α. Anti-oestrogenic drugs are the
standard treatment for these breast cancers; however, treatment resistance is common …
standard treatment for these breast cancers; however, treatment resistance is common …
[HTML][HTML] Amnion-epithelial-cell-derived exosomes demonstrate physiologic state of cell under oxidative stress
S Sheller, J Papaconstantinou, R Urrabaz-Garza… - PloS one, 2016 - journals.plos.org
At term, the signals of fetal maturity and feto-placental tissue aging prompt uterine readiness
for delivery by transitioning quiescent myometrium to an active stage. It is still unclear how …
for delivery by transitioning quiescent myometrium to an active stage. It is still unclear how …
[HTML][HTML] The role of HSPB8, a component of the chaperone-assisted selective autophagy machinery, in cancer
R Cristofani, M Piccolella, V Crippa, B Tedesco… - Cells, 2021 - mdpi.com
The cellular response to cancer-induced stress is one of the major aspects regulating cancer
development and progression. The Heat Shock Protein B8 (HSPB8) is a small chaperone …
development and progression. The Heat Shock Protein B8 (HSPB8) is a small chaperone …
[HTML][HTML] Posttranslationally modified progesterone receptors direct ligand-specific expression of breast cancer stem cell-associated gene programs
Background Estrogen and progesterone are potent breast mitogens. In addition to steroid
hormones, multiple signaling pathways input to estrogen receptor (ER) and progesterone …
hormones, multiple signaling pathways input to estrogen receptor (ER) and progesterone …
Progesterone and overlooked endocrine pathways in breast cancer pathogenesis
Worldwide, breast cancer incidence has been increasing for decades. Exposure to
reproductive hormones, as occurs with recurrent menstrual cycles, affects breast cancer risk …
reproductive hormones, as occurs with recurrent menstrual cycles, affects breast cancer risk …
[HTML][HTML] Steroid hormone receptors: links with cell cycle machinery and breast cancer progression
Progression of cells through cell cycle consists of a series of events orchestrated in a
regulated fashion. Such processes are influenced by cell cycle regulated expression of …
regulated fashion. Such processes are influenced by cell cycle regulated expression of …