The Klotho protein is a recently discovered protein and its overexpression is associated with
life extension. Klotho deficiency or silencing of the Klotho gene in mice leads to an …

Brain expression of klotho was first described with the initial discovery of the klotho gene.
The prominent age-regulating effects of klotho are attributed to regulation of ion homeostasis …

Klotho, which is a life extension factor, and erythropoietin (EPO) have been introduced as
effective neuroprotective factors in several neurological disorders. The present study is an …

Klotho, a gene found on chromosome 13q12, is involved in a variety of processes and
signaling pathways in the human body related to vitamin D metabolism; cardiovascular …

Cellular stress can lead to the production of reactive oxygen species (ROS) while
autophagy, as a catabolic pathway, protects the cells against stress. Autophagy in its turn …

Neuropsychiatric disorders are mainly concerned with the behavioural, emotional and
cognition symptoms that may be due to disturbed cerebral functions or extracerebral …

ندــب یاه هاگتــسد رتــشيب رــب یدــيفم تارــثا یرــيپ دــض ريــسکا کــی ناوــنع هب یوــتولک:
هــمدقم زا یرايــسب رد وــتولک دــيفم تارــثا رــب یــنبم یداــیز تاــشرازگ رــيخا هــهد ود رد. دراد …‎

Background we recently showed that a hypothesized anti-aging and anti-inflammatory
protein, namely Klotho, may contribute to the etiology and/or pathogenesis of multiple …

Soluble Klotho protein is present in blood, urine, and cerebrospinal fluid and works as a
humoral factor exerting different biological effects. Several animal studies have …

OBJECTIVE: Bipolar disorder (manic episode) is an essential psychiatric disorder with
unknown etiology, in which inflammation is considered to play a role. Klotho and FGF-23 are …