Enantioselective total syntheses of (+)-stemofoline and three congeners based on a biogenetic hypothesis

XZ Huang, LH Gao, PQ Huang - Nature Communications, 2020 - nature.com
The powerful insecticidal and multi-drug-resistance-reversing activities displayed by the
stemofoline group of alkaloids render them promising lead structures for further …

Identification of NLRP3 as a covalent target of 1, 6-O, O-diacetylbritannilactone against neuroinflammation by quantitative thiol reactivity profiling (QTRP)

MR Wang, LF Huang, C Guo, J Yang, S Dong… - Bioorganic …, 2022 - Elsevier
Neuroinflammation plays a key etiological role in the progressive neuronal damage of
neurodegenerative diseases. Our phenotypic-based screening discovered 1, 6-O, O …

Rapid Generation of Molecular Complexity by Chemical Synthesis: Highly Efficient Total Synthesis of Hexacyclic Alkaloid (−)‐Chaetominine and Its Biosynthetic …

H Geng, PQ Huang - The Chemical Record, 2019 - Wiley Online Library
The efficiency becomes a key issue in today's natural product total synthesis. While
biomimetic synthesis is one of the most elegant strategies to achieve synthetic efficiency and …

Selective and sensitive fluorescence “turn-on” Zn2+ probes based on combination of anthracene, diphenylamine and dipyrrin

X Wei, L Bu, W Tang, S Zhao, Y Xie - Science China Chemistry, 2017 - Springer
Two fluorescence “turn-on” Zn 2+ probes were developed by introducing an anthracenyl
fluorophore through the linkage of a diphenylamino moiety at the 5-position of a dipyrrin …

Total synthesis of the actinoallolides and a designed photoaffinity probe for target identification

MJ Anketell, TM Sharrock, I Paterson - Organic & Biomolecular …, 2020 - pubs.rsc.org
The actinoallolides are a family of polyketide natural products isolated from the bacterium
Actinoallomurus fulvus. They show potent biological activity against trypanosomes, the …

ent-Jungermannenone C Triggers Reactive Oxygen Species-Dependent Cell Differentiation in Leukemia Cells

Z Yue, X Xiao, J Wu, X Zhou, W Liu, Y Liu… - Journal of natural …, 2018 - ACS Publications
Acute myeloid leukemia (AML) is a hematologic malignancy that is characterized by clonal
proliferation of myeloid blasts. Despite the progress that has been made in the treatment of …

[PDF][PDF] Chemoproteomics as a versatile approach for the study and identification of the target enzymes of neratinib in Arabidopsis thaliana

S Ninck - 2023 - d-nb.info
The identification of (direct) molecular target enzymes of small molecule inhibitors is still one
of the major bottlenecks in chemical biology and drug discovery1, 2. For the assessment of …