Proteomics technologies for cancer liquid biopsies
Alterations in DNAs could not reveal what happened in proteins. The accumulated
alterations of DNAs would change the manifestation of proteins. Therefore, as is the case in …
alterations of DNAs would change the manifestation of proteins. Therefore, as is the case in …
Emerging epigenomic landscapes of pancreatic cancer in the era of precision medicine
Genetic studies have advanced our understanding of pancreatic cancer at a mechanistic
and translational level. Genetic concepts and tools are increasingly starting to be applied to …
and translational level. Genetic concepts and tools are increasingly starting to be applied to …
High-throughput profiling of histone post-translational modifications and chromatin modifying proteins by reverse phase protein array
Epigenetic variation plays a significant role in normal development and human diseases
including cancer, in part through post-translational modifications (PTMs) of histones …
including cancer, in part through post-translational modifications (PTMs) of histones …
Advancements in oncoproteomics technologies: Treading toward translation into clinical practice
Proteomics continues to forge significant strides in the discovery of essential biological
processes, uncovering valuable information on the identity, global protein abundance …
processes, uncovering valuable information on the identity, global protein abundance …
[HTML][HTML] In vitro antioxidant, antibacterial, cytotoxic, and epigenetic screening of crude extract and fractions of the marine sponge Neopetrosia exigua from Mauritius …
The marine sponge Neopetrosia exigua is known as a goldmine of novel compounds, yet its
pharmacological activities remain poorly characterised. Herein, this study investigates the …
pharmacological activities remain poorly characterised. Herein, this study investigates the …
Epigenetic approaches to overcome fluoropyrimidines resistance in solid tumors
L Grumetti, R Lombardi, F Iannelli, B Pucci, A Avallone… - Cancers, 2022 - mdpi.com
Simple Summary Fluoropyrimidines represent the backbone of many combination
chemotherapy regimens for the treatment of solid cancers but are still associated with toxicity …
chemotherapy regimens for the treatment of solid cancers but are still associated with toxicity …
Proteomics for cancer drug design
Introduction: Signal transduction cascades drive cellular proliferation, apoptosis, immune,
and survival pathways. Proteins have emerged as actionable drug targets because they are …
and survival pathways. Proteins have emerged as actionable drug targets because they are …
Profiling histone posttranslational modifications and chromatin-modifying proteins by high-throughput reverse phase protein array
Epigenetic variation contributes significantly to a wide range of activities, from normal
development to human diseases through alteration of chromatin organization and gene …
development to human diseases through alteration of chromatin organization and gene …
Multiplexed molecular imaging identifies pancreatic cancer candidates for epigenetic modulators
K Szymonski, N Janiszewska, K Sofińska… - 2024 - researchsquare.com
Genomic alterations drive the tumorigenesis of pancreatic cancer (PC). However, alone they
do not explain its numerous phenotypes. Exploring the epigenetic landscapes of PC delivers …
do not explain its numerous phenotypes. Exploring the epigenetic landscapes of PC delivers …
Beyond the genome: challenges and potential for epigenetics-driven therapeutic approaches in pulmonary arterial hypertension
Pulmonary arterial hypertension (PAH) is a devastating disease of the cardiopulmonary
system caused by the narrowing of the pulmonary arteries, leading to increased vascular …
system caused by the narrowing of the pulmonary arteries, leading to increased vascular …