The adenosine A2A receptor is a G-protein-coupled receptor (GPCR) that has been
extensively studied during the past few decades because it offers numerous possibilities for …

Non-human primate (NHP) models of Parkinson's disease (PD) have been essential in
understanding the pathophysiology and neural mechanisms underlying PD. The most …

Although deep brain electrical stimulation can alleviate the motor symptoms of Parkinson
disease (PD), just a small fraction of patients with PD can take advantage of this procedure …

This Review summarizes and updates the work on adenosine A2A receptor antagonists for
Parkinson's disease from 2006 to the present. There have been numerous publications …

Abstract Parkinson's disease (PD), a neurodegenerative disorder, is traditionally classified
as a movement disorder. Patients typically suffer from many motor dysfunctions. Presently …

Autism is a predominant neurodevelopmental disorder characterized by impaired
communication, social deficits, and repetitive behaviors. Recent research has proposed that …

The design and characterization of two, dual adenosine A2A/A1 receptor antagonists in
several animal models of Parkinson's disease is described. Compound 1 was previously …

Human embryonic stem cells (hESCs) differentiate into specialized cells, including midbrain
dopaminergic neurons (DANs), and Non-human primates (NHPs) injected with 1-methyl-4 …

The in vivo characterization of a dual adenosine A2A/A1 receptor antagonist in several
animal models of Parkinson's disease is described. Discovery and scale-up syntheses of …

Non-human primate (NHP) models of Parkinson disease show many similarities with the
human disease. They are very useful to test novel pharmacotherapies as reviewed here …