The abnormal regulation of alternative splicing is usually accompanied by the occurrence
and development of tumors, which would produce multiple different isoforms and diversify …

Transcription of eukaryotic genes by RNA polymerase II (Pol II) yields RNA precursors
containing introns that must be spliced out and the flanking exons ligated together. Splicing …

Cells produce multiple mRNAs through alternative splicing, which ensures proteome
diversity. Because most human genes undergo alternative splicing, key components of …

Ovarian cancer is the second leading cause of gynecologic cancer death worldwide, with
only 20% of cases detected early due to its elusive nature, limiting successful treatment …

In eukaryotes, splice sites define the introns of pre-mRNAs and must be recognized and
excised with nucleotide precision by the spliceosome to make the correct mRNA product. In …

ABSTRACT U1 snRNP is one of the most abundant ribonucleoprotein (RNP) complexes in
eukaryotic cells and is estimated to be approximately 1 million copies per cell. Apart from its …

Heterogeneous nuclear ribonucleoproteins (hnRNPs) are a superfamily of RNA-binding
proteins consisting of more than 20 members. These proteins play a crucial role in various …

Circular RNAs (circRNAs) lack the 5'-end methylated guanine cap structure and
3'polyadenylate tail structure, classifying it as a non-coding RNA. With the extensive …

In the TAR RNA of immunodeficiency viruses, an allosteric communication exists between a
distant loop and a bulge. The bulge interacts with the TAT protein vital for transactivating …

Deep intron space harbors a diverse array of splicing regulatory elements that cooperate
with better‐known exon‐proximal elements to enforce proper tissue‐specific and …