[HTML][HTML] Traumatic spinal cord injury: an overview of pathophysiology, models and acute injury mechanisms
A Alizadeh, SM Dyck, S Karimi-Abdolrezaee - Frontiers in neurology, 2019 - frontiersin.org
Traumatic spinal cord injury (SCI) is a life changing neurological condition with substantial
socioeconomic implications for patients and their care-givers. Recent advances in medical …
socioeconomic implications for patients and their care-givers. Recent advances in medical …
Immune cell compartmentalization for brain surveillance and protection
For decades, it was commonly accepted that the brain is secluded from peripheral immune
activity and is self-sufficient for its maintenance and repair. This simplistic perception was …
activity and is self-sufficient for its maintenance and repair. This simplistic perception was …
The biology of regeneration failure and success after spinal cord injury
Since no approved therapies to restore mobility and sensation following spinal cord injury
(SCI) currently exist, a better understanding of the cellular and molecular mechanisms …
(SCI) currently exist, a better understanding of the cellular and molecular mechanisms …
[HTML][HTML] Spinal cord injury scarring and inflammation: therapies targeting glial and inflammatory responses
MB Orr, JC Gensel - Neurotherapeutics, 2018 - Elsevier
Deficits in neuronal function are a hallmark of spinal cord injury (SCI) and therapeutic efforts
are often focused on central nervous system (CNS) axon regeneration. However, secondary …
are often focused on central nervous system (CNS) axon regeneration. However, secondary …
The influence of neuroinflammation in Autism Spectrum Disorder
Abstract Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterised
by deficits in social communication and restricted or repetitive behaviours. The clinical …
by deficits in social communication and restricted or repetitive behaviours. The clinical …
Interaction of reactive astrocytes with type I collagen induces astrocytic scar formation through the integrin–N-cadherin pathway after spinal cord injury
M Hara, K Kobayakawa, Y Ohkawa, H Kumamaru… - Nature medicine, 2017 - nature.com
Central nervous system (CNS) injury transforms naive astrocytes into reactive astrocytes,
which eventually become scar-forming astrocytes that can impair axonal regeneration and …
which eventually become scar-forming astrocytes that can impair axonal regeneration and …
Proteoglycan chemical diversity drives multifunctional cell regulation and therapeutics
The extracellular matrix (ECM) constitutes a highly dynamic three-dimensional structural
network comprised of macromolecules, such as proteoglycans/glycosaminoglycans …
network comprised of macromolecules, such as proteoglycans/glycosaminoglycans …
Microglial and macrophage polarization—new prospects for brain repair
The traditional view of the adult brain as a static organ has changed in the past three
decades, with the emergence of evidence that it remains plastic and has some regenerative …
decades, with the emergence of evidence that it remains plastic and has some regenerative …
Peripherally derived macrophages can engraft the brain independent of irradiation and maintain an identity distinct from microglia
Peripherally derived macrophages infiltrate the brain after bone marrow transplantation and
during central nervous system (CNS) inflammation. It was initially suggested that these …
during central nervous system (CNS) inflammation. It was initially suggested that these …
Alternatively activated microglia and macrophages in the central nervous system
R Franco, D Fernández-Suárez - Progress in neurobiology, 2015 - Elsevier
Macrophages are important players in the fight against viral, bacterial, fungal and parasitic
infections. From a resting state they may undertake two activation pathways, the classical …
infections. From a resting state they may undertake two activation pathways, the classical …