Infections caused by Gram‐positive and‐negative bacteria are one of the foremost causes of
morbidity and mortality globally. Antibiotics are the mainstay of therapy for bacterial …

Developing novel chemical entities via different reactions and mechanisms is one of the
hottest topics in drug development. The coumarin moiety displays good cell permeability …

ABSTRACT A series of 5-(4-substituted phenyl)-1, 3, 4-thiadiazole-2-amines (4a-h) were
prepared from dehydrocyclization of 4-substituted benzoyl thiosemicarbazides (3a-h) using …

Purpose: To design isatin-based compounds, carry out in silico studies, and identify the
biologically active isatin derivatives. Methods: Fourteen isatin-based compounds (A to N) …

Mannich bases are a class of organic compounds usually obtained by the condensation
reaction between an amine, a compound with active hydrogens, and an aldehyde. They are …

Background A new series of 2-(2-(substituted aldehyde) hydrazinyl)-4-(2-chlorophenyl)-1-
methyl-6-oxo-1, 6-dihydropyrimidine-5-carbonitrile analogs (1–19) was prepared by using …

Methods: The reaction of the intermediates (2a-2c) with 3a-3c in acetone/potassium
carbonate solution yielded 4a-4i, which were characterized using Fourier-transform infrared …

A facile and efficient one-pot synthesis of 3-(furan-2-yl)-4-hydroxy-2H-chromen-2-ones was
developed. The reaction of ethyl 3-(2-hydroxyphenyl)-3-oxopropanoates and 2, 5-dimethoxy …

Purpose: To prepare and evaluate some 2-piperidinomethylamino-4-(7-
H/substitutedcoumarin-3-yl)-6-chlorosubstitutedphenyl pyrimidines as antimicrobial agents …

Purpose: To prepare and evaluate some quinoline-pyrazoline-based naphthalenyl thiazole
derivatives as antimicrobial agents. Methods: Some quinoline-pyrazoline-based …