Breathing and tilting: mesoscale simulations illuminate influenza glycoprotein vulnerabilities

L Casalino, C Seitz, J Lederhofer… - ACS Central …, 2022 - ACS Publications
Influenza virus has resurfaced recently from inactivity during the early stages of the COVID-
19 pandemic, raising serious concerns about the nature and magnitude of future epidemics …

Chimeric hemagglutinin split vaccines elicit broadly cross-reactive antibodies and protection against group 2 influenza viruses in mice

E Puente-Massaguer, K Vasilev, A Beyer… - Science …, 2023 - science.org
Seasonal influenza virus vaccines are effective when they are well matched to circulating
strains. Because of antigenic drift/change in the immunodominant hemagglutinin (HA) head …

[HTML][HTML] Triple tandem trimer immunogens for HIV-1 and influenza nucleic acid-based vaccines

I del Moral-Sánchez, EG Wee, Y Xian, WH Lee… - npj Vaccines, 2024 - nature.com
Recombinant native-like HIV-1 envelope glycoprotein (Env) trimers are used in candidate
vaccines aimed at inducing broadly neutralizing antibodies. While state-of-the-art SOSIP or …

Synthesis and pharmacodynamic evaluation of naphthalene derivatives against influenza A virus in vitro and in vivo

Y Ge, C Zhang, Y Qu, L Ding, X Zhang, Z Zhang… - European Journal of …, 2023 - Elsevier
Influenza A virus is a highly mutable pathogenic pathogen that could cause a global
pandemic. It is necessary to find new anti-influenza drugs to resist influenza epidemics due …

Characterization of passive microfluidic mixer with a three-dimensional zig-zag channel for cryo-EM sampling

B Lee, M Kim, S Oh, DB Lee, SG Lee, HM Kim… - Chemical Engineering …, 2023 - Elsevier
Microfluidic mixing is an essential unit operation in miniaturized analytical systems.
Achieving high mixing efficiency is considerably difficult in conventional microfluidic …

[HTML][HTML] Eliciting a single amino acid change by vaccination generates antibody protection against group 1 and group 2 influenza A viruses

R Ray, FAN Mohamed, DP Maurer, J Huang, BA Alpay… - Immunity, 2024 - cell.com
Broadly neutralizing antibodies (bnAbs) targeting the hemagglutinin (HA) stem of influenza
A viruses (IAVs) tend to be effective against either group 1 or group 2 viral diversity. In rarer …

[PDF][PDF] Antigen spacing on protein nanoparticles influences antibody responses to vaccination

D Ellis, A Dosey, S Boyoglu-Barnum, YJ Park… - Cell reports, 2023 - cell.com
Immunogen design approaches aim to control the specificity and quality of antibody
responses elicited by next-generation vaccines. Here, we use computational protein design …

Antibody inhibition of influenza A virus assembly and release

Y He, Z Guo, S Subiaur, A Benegal… - Journal of …, 2024 - Am Soc Microbiol
Antibodies are frontline defenders against influenza virus infection, providing protection
through multiple complementary mechanisms. Although a subset of monoclonal antibodies …

[HTML][HTML] Sequential Immunizations with Influenza Neuraminidase Protein Followed by Peptide Nanoclusters Induce Heterologous Protection

WW Song, MY Wan, JY She, SL Zhao, DJ Liu… - Viruses, 2024 - mdpi.com
Enhancing cross-protections against diverse influenza viruses is desired for influenza
vaccinations. Neuraminidase (NA)-specific antibody responses have been found to …

Breathing and Tilting: Mesoscale Simulations Illuminate Influenza Glycoprotein Vulnerabilities.

J Lederhofer, Y Tsybovsky, I Wilson… - ACS Central …, 2022 - escholarship.org
Influenza virus has resurfaced recently from inactivity during the early stages of the COVID-
19 pandemic, raising serious concerns about the nature and magnitude of future epidemics …