Cellular mechanotransduction: from tension to function
F Martino, AR Perestrelo, V Vinarský, S Pagliari… - Frontiers in …, 2018 - frontiersin.org
Living cells are constantly exposed to mechanical stimuli arising from the surrounding
extracellular matrix (ECM) or from neighboring cells. The intracellular molecular processes …
extracellular matrix (ECM) or from neighboring cells. The intracellular molecular processes …
Actin–microtubule crosstalk in cell biology
M Dogterom, GH Koenderink - Nature reviews Molecular cell biology, 2019 - nature.com
The cytoskeleton and its components—actin, microtubules and intermediate filaments—
have been studied for decades, and multiple roles of the individual cytoskeletal …
have been studied for decades, and multiple roles of the individual cytoskeletal …
Mechanical force-driven adherens junction remodeling and epithelial dynamics
D Pinheiro, Y Bellaiche - Developmental cell, 2018 - cell.com
During epithelial tissue development, repair, and homeostasis, adherens junctions (AJs)
ensure intercellular adhesion and tissue integrity while allowing for cell and tissue …
ensure intercellular adhesion and tissue integrity while allowing for cell and tissue …
Spindle positioning and its impact on vertebrate tissue architecture and cell fate
T Lechler, M Mapelli - Nature Reviews Molecular Cell Biology, 2021 - nature.com
In multicellular systems, oriented cell divisions are essential for morphogenesis and
homeostasis as they determine the position of daughter cells within the tissue and also, in …
homeostasis as they determine the position of daughter cells within the tissue and also, in …
Regulation of mitotic spindle orientation: an integrated view
Mitotic spindle orientation is essential for cell fate decisions, epithelial maintenance, and
tissue morphogenesis. In most animal cell types, the dynein motor complex is anchored at …
tissue morphogenesis. In most animal cell types, the dynein motor complex is anchored at …
Nanoscale surfaces for the long-term maintenance of mesenchymal stem cell phenotype and multipotency
There is currently an unmet need for the supply of autologous, patient-specific stem cells for
regenerative therapies in the clinic. Mesenchymal stem cell differentiation can be driven by …
regenerative therapies in the clinic. Mesenchymal stem cell differentiation can be driven by …
Roles of the cytoskeleton, cell adhesion and rho signalling in mechanosensing and mechanotransduction
K Ohashi, S Fujiwara, K Mizuno - The journal of biochemistry, 2017 - academic.oup.com
All cells sense and respond to various mechanical forces in and mechanical properties of
their environment. To respond appropriately, cells must be able to sense the location …
their environment. To respond appropriately, cells must be able to sense the location …
Mechanobiology and developmental control
T Mammoto, A Mammoto… - Annual review of cell and …, 2013 - annualreviews.org
Morphogenesis is the remarkable process by which cells self-assemble into complex tissues
and organs that exhibit specialized form and function during embryological development …
and organs that exhibit specialized form and function during embryological development …
Multiscale force sensing in development
NI Petridou, Z Spiró, CP Heisenberg - Nature cell biology, 2017 - nature.com
The seminal observation that mechanical signals can elicit changes in biochemical
signalling within cells, a process commonly termed mechanosensation and …
signalling within cells, a process commonly termed mechanosensation and …
Innovative tools for mechanobiology: unraveling outside-in and inside-out mechanotransduction
D Mohammed, M Versaevel, C Bruyère… - … in Bioengineering and …, 2019 - frontiersin.org
Cells and tissues can sense and react to the modifications of the physico-chemical
properties of the extracellular environment (ECM) through integrin-based adhesion sites and …
properties of the extracellular environment (ECM) through integrin-based adhesion sites and …