Parkinson's disease (PD) is a neurodegenerative disease with a 200 year-long research
history. Our understanding about its clinical phenotype and pathogenesis remains limited …

Patients with Parkinson's disease present with signs and symptoms of dysregulation of the
peripheral autonomic nervous system that can even precede motor deficits. This …

Many chronic disease symptomatologies involve desynchronized sleep-wake cycles,
indicative of disrupted biorhythms. This can be interrogated using body temperature …

Thermoregulation is a mechanism by which mammals maintain body temperature with
tightly controlled self-regulation independent of external temperatures. Temperature …

Parkinson's disease is associated with a variety of dermatologic disorders and the study of
skin may provide insights into pathophysiological mechanisms underlying this common …

Identification of Parkinson's disease subtypes may help understand underlying disease
mechanisms and provide personalized management. Although clustering methods have …

Background: Previous studies have identified low serum uric acid (SUA) levels as a risk
factor for the development of Parkinson's disease (PD). Prodromal PD mainly manifests as a …

Recognition of the importance of nonmotor dysfunction as a component of Parkinson's
disease has exploded over the past three decades. Autonomic dysfunction is a frequent and …

Nonmotor symptoms negatively affect health-related quality of life (HRQoL) in patients with
Parkinson's disease (PD). However, it is unknown which nonmotor symptoms are most …

This study hypothesized that botulinum toxin (Botox) therapy would sustainably reduce
sweat production in axillary hyperhidrosis patients over one year and significantly improve …